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Fibroblast-derived matrix human skin equivalents reveal distinct roles for papillary and reticular fibroblasts in human skin barrier integrity and aging.

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Title: Fibroblast-derived matrix human skin equivalents reveal distinct roles for papillary and reticular fibroblasts in human skin barrier integrity and aging.
Authors: Louis A; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands. a.louis@lumc.nl., Mergen C; Leiden Academic Centre for Drug Research, Leiden university, Leiden, The Netherlands., Rietveld MH; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands., Gendronneau G; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France., Andre N; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France., Ben Khalifa Y; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France., Bouwstra JA; Leiden Academic Centre for Drug Research, Leiden university, Leiden, The Netherlands., Rissmann R; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands.; Leiden Academic Centre for Drug Research, Leiden university, Leiden, The Netherlands.; Centre for Human Drug Research, Leiden, The Netherlands., Halkoum R; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France., El Ghalbzouri A; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands.
Source: Scientific reports [Sci Rep] 2026 Apr 16; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-026-48648-3