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Fibroblast-derived matrix human skin equivalents reveal distinct roles for papillary and reticular fibroblasts in human skin barrier integrity and aging.

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Title: Fibroblast-derived matrix human skin equivalents reveal distinct roles for papillary and reticular fibroblasts in human skin barrier integrity and aging.
Authors: Louis A; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands. a.louis@lumc.nl., Mergen C; Leiden Academic Centre for Drug Research, Leiden university, Leiden, The Netherlands., Rietveld MH; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands., Gendronneau G; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France., Andre N; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France., Ben Khalifa Y; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France., Bouwstra JA; Leiden Academic Centre for Drug Research, Leiden university, Leiden, The Netherlands., Rissmann R; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands.; Leiden Academic Centre for Drug Research, Leiden university, Leiden, The Netherlands.; Centre for Human Drug Research, Leiden, The Netherlands., Halkoum R; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France., El Ghalbzouri A; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands.
Source: Scientific reports [Sci Rep] 2026 Apr 16; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fibroblast-derived matrix human skin equivalents reveal distinct roles for papillary and reticular fibroblasts in human skin barrier integrity and aging.
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  Data: <searchLink fieldCode="AU" term="%22Louis+A%22">Louis A</searchLink>; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands. a.louis@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Mergen+C%22">Mergen C</searchLink>; Leiden Academic Centre for Drug Research, Leiden university, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rietveld+MH%22">Rietveld MH</searchLink>; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gendronneau+G%22">Gendronneau G</searchLink>; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France.<br /><searchLink fieldCode="AU" term="%22Andre+N%22">Andre N</searchLink>; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France.<br /><searchLink fieldCode="AU" term="%22Ben+Khalifa+Y%22">Ben Khalifa Y</searchLink>; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France.<br /><searchLink fieldCode="AU" term="%22Bouwstra+JA%22">Bouwstra JA</searchLink>; Leiden Academic Centre for Drug Research, Leiden university, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rissmann+R%22">Rissmann R</searchLink>; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands.; Leiden Academic Centre for Drug Research, Leiden university, Leiden, The Netherlands.; Centre for Human Drug Research, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Halkoum+R%22">Halkoum R</searchLink>; Innovation Research & Development, CHANEL Fragrances & Beauty, Pantin, France.<br /><searchLink fieldCode="AU" term="%22El+Ghalbzouri+A%22">El Ghalbzouri A</searchLink>; Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, 071 52 66747, Leiden, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Apr 16; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Apr 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 16
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