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Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial.

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Title: Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial.
Authors: Lu Z; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Wang Z; Department of Neurology, Linyi People's Hospital, Linyi, China., Jin A; China National Clinical Research Center for Neurological Diseases, Beijing, China., Che F; Department of Neurology, Linyi People's Hospital, Linyi, China., Wang L; Department of Neurology, Second Affiliated Hospital of Harbin Medical University, Harbin, China., Zhou L; Department of Neurology, Weifang People's Hospital, Weifang, China., Dai H; Department of Emergency Medicine, Linfen Central Hospital, Linfen, China., Liu X; Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, China., Cao Z; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Wang L; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Hao M; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Ye W; China National Clinical Research Center for Neurological Diseases, Beijing, China., Xiong Y; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. xiongyunyun@bjtth.org.; China National Clinical Research Center for Neurological Diseases, Beijing, China. xiongyunyun@bjtth.org., Wang Y; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. yongjunwang@ncrcnd.org.cn.; China National Clinical Research Center for Neurological Diseases, Beijing, China. yongjunwang@ncrcnd.org.cn.
Source: BMC medicine [BMC Med] 2026 Apr 16; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Lu+Z%22">Lu Z</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Neurology, Linyi People's Hospital, Linyi, China.<br /><searchLink fieldCode="AU" term="%22Jin+A%22">Jin A</searchLink>; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Che+F%22">Che F</searchLink>; Department of Neurology, Linyi People's Hospital, Linyi, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Neurology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Department of Neurology, Weifang People's Hospital, Weifang, China.<br /><searchLink fieldCode="AU" term="%22Dai+H%22">Dai H</searchLink>; Department of Emergency Medicine, Linfen Central Hospital, Linfen, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cao+Z%22">Cao Z</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Hao+M%22">Hao M</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ye+W%22">Ye W</searchLink>; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. xiongyunyun@bjtth.org.; China National Clinical Research Center for Neurological Diseases, Beijing, China. xiongyunyun@bjtth.org.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. yongjunwang@ncrcnd.org.cn.; China National Clinical Research Center for Neurological Diseases, Beijing, China. yongjunwang@ncrcnd.org.cn.
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  Data: <searchLink fieldCode="JN" term="%22101190723%22">BMC medicine</searchLink> [BMC Med] 2026 Apr 16; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Apr 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190723 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1741-7015 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217417015%22">17417015 </searchLink><i>NLM ISO Abbreviation: </i>BMC Med <i>Subsets: </i>MEDLINE
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