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Measuring and appraising placebo effects in clinical trials: contemporary challenges and approaches in psychiatry.

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Title: Measuring and appraising placebo effects in clinical trials: contemporary challenges and approaches in psychiatry.
Authors: Taylor JJ; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Center for Brain Circuit Therapeutics, Mass General Brigham, Boston, MA, USA; Department of Psychiatry, Mass General Brigham, Boston, MA, USA., Szigeti B; Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Centre for Psychedelic Research, Imperial College London, London, UK., Silverberg ND; Department of Psychology, University of British Columbia, Vancouver, BC, Canada; Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada., Ahmadzad-Asl M; Department of Psychiatry, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada., Kare M; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Center for Brain Circuit Therapeutics, Mass General Brigham, Boston, MA, USA; Department of Psychiatry, Mass General Brigham, Boston, MA, USA., Webler R; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Center for Brain Circuit Therapeutics, Mass General Brigham, Boston, MA, USA; Department of Psychiatry, Mass General Brigham, Boston, MA, USA., Orsini DK; Department of Psychiatry, University Health Network, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Rosenblat JD; Department of Psychiatry, University Health Network, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty Medicine, University of Toronto, Toronto, ON, Canada., Bschor T; Department of Psychiatry and Psychotherapy, University Hospital, Technical University of Dresden, Dresden, Germany., Baethge C; Department of Psychiatry and Psychotherapy, University of Cologne Medical School, Cologne, Germany., Sinyor M; Department of Psychiatry, Temerty Faculty Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Sunnybrook Health Science Centre, Toronto, ON, Canada., Nicholson TR; King's College London, London, England., Wager TD; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA., Burke MJ; Department of Psychiatry, Temerty Faculty Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Sunnybrook Health Science Centre, Toronto, ON, Canada; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Center, University of Toronto, Toronto. Electronic address: matt.burke@utoronto.ca.
Source: The lancet. Psychiatry [Lancet Psychiatry] 2026 May; Vol. 13 (5), pp. 426-440.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101638123 Publication Model: Print Cited Medium: Internet ISSN: 2215-0374 (Electronic) Linking ISSN: 22150366 NLM ISO Abbreviation: Lancet Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Taylor+JJ%22">Taylor JJ</searchLink>; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Center for Brain Circuit Therapeutics, Mass General Brigham, Boston, MA, USA; Department of Psychiatry, Mass General Brigham, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Szigeti+B%22">Szigeti B</searchLink>; Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Centre for Psychedelic Research, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Silverberg+ND%22">Silverberg ND</searchLink>; Department of Psychology, University of British Columbia, Vancouver, BC, Canada; Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Ahmadzad-Asl+M%22">Ahmadzad-Asl M</searchLink>; Department of Psychiatry, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Kare+M%22">Kare M</searchLink>; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Center for Brain Circuit Therapeutics, Mass General Brigham, Boston, MA, USA; Department of Psychiatry, Mass General Brigham, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Webler+R%22">Webler R</searchLink>; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Center for Brain Circuit Therapeutics, Mass General Brigham, Boston, MA, USA; Department of Psychiatry, Mass General Brigham, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Orsini+DK%22">Orsini DK</searchLink>; Department of Psychiatry, University Health Network, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rosenblat+JD%22">Rosenblat JD</searchLink>; Department of Psychiatry, University Health Network, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bschor+T%22">Bschor T</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, Technical University of Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Baethge+C%22">Baethge C</searchLink>; Department of Psychiatry and Psychotherapy, University of Cologne Medical School, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Sinyor+M%22">Sinyor M</searchLink>; Department of Psychiatry, Temerty Faculty Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Sunnybrook Health Science Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Nicholson+TR%22">Nicholson TR</searchLink>; King's College London, London, England.<br /><searchLink fieldCode="AU" term="%22Wager+TD%22">Wager TD</searchLink>; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.<br /><searchLink fieldCode="AU" term="%22Burke+MJ%22">Burke MJ</searchLink>; Department of Psychiatry, Temerty Faculty Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Sunnybrook Health Science Centre, Toronto, ON, Canada; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Center, University of Toronto, Toronto. Electronic address: matt.burke@utoronto.ca.
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