Maternal-prenatal gut microbiome-systemic metabolome perturbations and TH2-skewed immunity link to offspring gut microbiome disruption and atopic dermatitis susceptibility.
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| Title: | Maternal-prenatal gut microbiome-systemic metabolome perturbations and T |
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| Authors: | Ng DZW; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore., Yap GC; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore., Tay CJX; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore., Huang CH; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore., Zhao S; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore., Low A; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore., Tham EH; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Division of Allergy & Immunology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Loo EXL; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, NUS, Singapore, Singapore., Shek LP; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore., Goh A; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Chong KW; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Goh SH; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Cheng ZR; Respiratory Medicine Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Van Bever HPS; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Teoh OH; Respiratory Medicine Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Lee YS; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Division of Paediatric Endocrinology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Yap F; Department of Paediatrics Endocrinology, KK Women's and Children's Hospital, Singapore, Singapore., Tan KH; Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore., Chong YS; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chan SY; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Eriksson JG; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland., Godfrey KM; MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Lay C; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Danone Research and Innovation, Precision Nutrition D-lab, Singapore, Singapore., Knol J; Danone Research and Innovation, Utrecht Center, Utrecht, The Netherlands.; APC Microbiome Ireland, University College Cork, Cork, Ireland., Schuster SC; Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore., Lai JS; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chong MF; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, #09-01Q, Singapore, 117549, Singapore., Lee JWJ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, E7, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.; Division of Gastroenterology & Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore., Lee BW; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. paeleebw@nus.edu.sg., Chan ECY; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore. phaccye@nus.edu.sg., Ta LDH; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. huy.ta@nus.edu.sg. |
| Source: | Genome medicine [Genome Med] 2026 Apr 17; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 17. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41998770 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Maternal-prenatal gut microbiome-systemic metabolome perturbations and T<subscript>H</subscript>2-skewed immunity link to offspring gut microbiome disruption and atopic dermatitis susceptibility. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ng+DZW%22">Ng DZW</searchLink>; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore.<br /><searchLink fieldCode="AU" term="%22Yap+GC%22">Yap GC</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+CJX%22">Tay CJX</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+CH%22">Huang CH</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Low+A%22">Low A</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Tham+EH%22">Tham EH</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Division of Allergy & Immunology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Loo+EXL%22">Loo EXL</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, NUS, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Shek+LP%22">Shek LP</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+A%22">Goh A</searchLink>; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+KW%22">Chong KW</searchLink>; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+SH%22">Goh SH</searchLink>; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Cheng+ZR%22">Cheng ZR</searchLink>; Respiratory Medicine Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Van+Bever+HPS%22">Van Bever HPS</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Teoh+OH%22">Teoh OH</searchLink>; Respiratory Medicine Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+YS%22">Lee YS</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Division of Paediatric Endocrinology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yap+F%22">Yap F</searchLink>; Department of Paediatrics Endocrinology, KK Women's and Children's Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+KH%22">Tan KH</searchLink>; Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+YS%22">Chong YS</searchLink>; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+SY%22">Chan SY</searchLink>; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Eriksson+JG%22">Eriksson JG</searchLink>; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Godfrey+KM%22">Godfrey KM</searchLink>; MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Lay+C%22">Lay C</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Danone Research and Innovation, Precision Nutrition D-lab, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Knol+J%22">Knol J</searchLink>; Danone Research and Innovation, Utrecht Center, Utrecht, The Netherlands.; APC Microbiome Ireland, University College Cork, Cork, Ireland.<br /><searchLink fieldCode="AU" term="%22Schuster+SC%22">Schuster SC</searchLink>; Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lai+JS%22">Lai JS</searchLink>; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+MF%22">Chong MF</searchLink>; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, #09-01Q, Singapore, 117549, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+JWJ%22">Lee JWJ</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, E7, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.; Division of Gastroenterology & Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+BW%22">Lee BW</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. paeleebw@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Chan+ECY%22">Chan ECY</searchLink>; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore. phaccye@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Ta+LDH%22">Ta LDH</searchLink>; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. huy.ta@nus.edu.sg. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101475844%22">Genome medicine</searchLink> [Genome Med] 2026 Apr 17; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 Apr 17. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101475844 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-994X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221756994X%22">1756994X </searchLink><i>NLM ISO Abbreviation: </i>Genome Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41998770 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13073-026-01655-5 Languages: – Code: eng Text: English Titles: – TitleFull: Maternal-prenatal gut microbiome-systemic metabolome perturbations and TH2-skewed immunity link to offspring gut microbiome disruption and atopic dermatitis susceptibility. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ng DZW – PersonEntity: Name: NameFull: Yap GC – PersonEntity: Name: NameFull: Tay CJX – PersonEntity: Name: NameFull: Huang CH – PersonEntity: Name: NameFull: Zhao S – PersonEntity: Name: NameFull: Low A – PersonEntity: Name: NameFull: Tham EH – PersonEntity: Name: NameFull: Loo EXL – PersonEntity: Name: NameFull: Shek LP – PersonEntity: Name: NameFull: Goh A – PersonEntity: Name: NameFull: Chong KW – PersonEntity: Name: NameFull: Goh SH – PersonEntity: Name: NameFull: Cheng ZR – PersonEntity: Name: NameFull: Van Bever HPS – PersonEntity: Name: NameFull: Teoh OH – PersonEntity: Name: NameFull: Lee YS – PersonEntity: Name: NameFull: Yap F – PersonEntity: Name: NameFull: Tan KH – PersonEntity: Name: NameFull: Chong YS – PersonEntity: Name: NameFull: Chan SY – PersonEntity: Name: NameFull: Eriksson JG – PersonEntity: Name: NameFull: Godfrey KM – PersonEntity: Name: NameFull: Lay C – PersonEntity: Name: NameFull: Knol J – PersonEntity: Name: NameFull: Schuster SC – PersonEntity: Name: NameFull: Lai JS – PersonEntity: Name: NameFull: Chong MF – PersonEntity: Name: NameFull: Lee JWJ – PersonEntity: Name: NameFull: Lee BW – PersonEntity: Name: NameFull: Chan ECY – PersonEntity: Name: NameFull: Ta LDH IsPartOfRelationships: – BibEntity: Dates: – D: 17 M: 04 Text: 2026 Apr 17 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1756-994X Numbering: – Type: volume Value: 18 – Type: issue Value: 1 Titles: – TitleFull: Genome medicine Type: main |
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