Maternal-prenatal gut microbiome-systemic metabolome perturbations and TH2-skewed immunity link to offspring gut microbiome disruption and atopic dermatitis susceptibility.

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Title: Maternal-prenatal gut microbiome-systemic metabolome perturbations and TH2-skewed immunity link to offspring gut microbiome disruption and atopic dermatitis susceptibility.
Authors: Ng DZW; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore., Yap GC; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore., Tay CJX; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore., Huang CH; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore., Zhao S; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore., Low A; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore., Tham EH; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Division of Allergy & Immunology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Loo EXL; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, NUS, Singapore, Singapore., Shek LP; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore., Goh A; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Chong KW; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Goh SH; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Cheng ZR; Respiratory Medicine Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Van Bever HPS; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Teoh OH; Respiratory Medicine Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore., Lee YS; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Division of Paediatric Endocrinology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Yap F; Department of Paediatrics Endocrinology, KK Women's and Children's Hospital, Singapore, Singapore., Tan KH; Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore., Chong YS; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chan SY; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Eriksson JG; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland., Godfrey KM; MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Lay C; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore.; Danone Research and Innovation, Precision Nutrition D-lab, Singapore, Singapore., Knol J; Danone Research and Innovation, Utrecht Center, Utrecht, The Netherlands.; APC Microbiome Ireland, University College Cork, Cork, Ireland., Schuster SC; Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore., Lai JS; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chong MF; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, #09-01Q, Singapore, 117549, Singapore., Lee JWJ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 14 Medical Drive, Singapore, 117599, Singapore.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, E7, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.; Division of Gastroenterology & Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore., Lee BW; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. paeleebw@nus.edu.sg., Chan ECY; Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore. phaccye@nus.edu.sg., Ta LDH; Department of Paediatrics, National University of Singapore, Yong Loo Lin School of Medicine, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. huy.ta@nus.edu.sg.
Source: Genome medicine [Genome Med] 2026 Apr 17; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1756-994X
DOI:10.1186/s13073-026-01655-5