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Dose-dependent cerebral metabolic impairment in a swine model of carbon monoxide poisoning.

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Title: Dose-dependent cerebral metabolic impairment in a swine model of carbon monoxide poisoning.
Authors: Lewis A; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, United States; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, United States., Forti RM; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States., Ko TS; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States., Greenwood JC; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Kelly M; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Shofer FS; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Kao SH; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States., Shin SS; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Bungatavula D; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Mason M; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States., Starr J; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States., Ehinger JK; Mitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Otorhinolaryngology, Head and Neck Surgery, Skåne University Hospital, Lund, Sweden; Otorhinolaryngology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Kilbaugh TJ; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States., Yodh AG; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, United States., Baker WB; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States., Jang DH; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address: david.jang@pennmedicine.uphs.edu.
Source: Neurotoxicology [Neurotoxicology] 2026 May; Vol. 114, pp. 103454. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9711 (Electronic) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lewis+A%22">Lewis A</searchLink>; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, United States; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Forti+RM%22">Forti RM</searchLink>; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Ko+TS%22">Ko TS</searchLink>; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Greenwood+JC%22">Greenwood JC</searchLink>; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+M%22">Kelly M</searchLink>; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Shofer+FS%22">Shofer FS</searchLink>; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Kao+SH%22">Kao SH</searchLink>; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Shin+SS%22">Shin SS</searchLink>; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Bungatavula+D%22">Bungatavula D</searchLink>; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Mason+M%22">Mason M</searchLink>; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Starr+J%22">Starr J</searchLink>; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Ehinger+JK%22">Ehinger JK</searchLink>; Mitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Otorhinolaryngology, Head and Neck Surgery, Skåne University Hospital, Lund, Sweden; Otorhinolaryngology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Kilbaugh+TJ%22">Kilbaugh TJ</searchLink>; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Yodh+AG%22">Yodh AG</searchLink>; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Baker+WB%22">Baker WB</searchLink>; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.<br /><searchLink fieldCode="AU" term="%22Jang+DH%22">Jang DH</searchLink>; Resuscitation Science Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address: david.jang@pennmedicine.uphs.edu.
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