Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants.

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Title: Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants.
Authors: Capener JL; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Vasta JD; Promega Corporation, Madison, WI, United States., Katis VL; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Michaud A; Promega Corporation, Madison, WI, United States., Beck MT; Promega Corporation, Madison, WI, United States., Daglish SCD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Cohen-Kedar S; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Barda ES; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Howell S; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Dotan I; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Robers MB; Promega Corporation, Madison, WI, United States., Axtman AD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Bashore FM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Source: Frontiers in chemical biology [Front Chem Biol] 2024; Vol. 3. Date of Electronic Publication: 2024 Jul 28.
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918716583206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2813-530X (Electronic) Linking ISSN: 2813530X NLM ISO Abbreviation: Front Chem Biol Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Capener+JL%22">Capener JL</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.<br /><searchLink fieldCode="AU" term="%22Vasta+JD%22">Vasta JD</searchLink>; Promega Corporation, Madison, WI, United States.<br /><searchLink fieldCode="AU" term="%22Katis+VL%22">Katis VL</searchLink>; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Michaud+A%22">Michaud A</searchLink>; Promega Corporation, Madison, WI, United States.<br /><searchLink fieldCode="AU" term="%22Beck+MT%22">Beck MT</searchLink>; Promega Corporation, Madison, WI, United States.<br /><searchLink fieldCode="AU" term="%22Daglish+SCD%22">Daglish SCD</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.<br /><searchLink fieldCode="AU" term="%22Cohen-Kedar+S%22">Cohen-Kedar S</searchLink>; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Barda+ES%22">Barda ES</searchLink>; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Howell+S%22">Howell S</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.<br /><searchLink fieldCode="AU" term="%22Dotan+I%22">Dotan I</searchLink>; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Robers+MB%22">Robers MB</searchLink>; Promega Corporation, Madison, WI, United States.<br /><searchLink fieldCode="AU" term="%22Axtman+AD%22">Axtman AD</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.<br /><searchLink fieldCode="AU" term="%22Bashore+FM%22">Bashore FM</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
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  Data: <searchLink fieldCode="JN" term="%229918716583206676%22">Frontiers in chemical biology</searchLink> [Front Chem Biol] 2024; Vol. 3. <i>Date of Electronic Publication: </i>2024 Jul 28.
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