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Development of a multi-targeted sulfonyl-bridged bisselenadiazole derivative as a potent EGFR/PI3K/AKT/mTOR modulator in lung adenocarcinoma.

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Title: Development of a multi-targeted sulfonyl-bridged bisselenadiazole derivative as a potent EGFR/PI3K/AKT/mTOR modulator in lung adenocarcinoma.
Authors: El-Fattah WA; Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) P. O. Box 5701 Riyadh 11432 Saudi Arabia amalkasme@imamu.edu.sa., Guesmi A; Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) P. O. Box 5701 Riyadh 11432 Saudi Arabia amalkasme@imamu.edu.sa., Ben Hamadi N; Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) P. O. Box 5701 Riyadh 11432 Saudi Arabia amalkasme@imamu.edu.sa., Sayed AR; Institute of Basic and Applied Science, Egypt-Japan University of Science and Technology Alexandria Egypt abdelwahed.rashad@ejust.edu.eg., El-Reedy AAM; Basic-Applied Science Department, Faculty of Oral and Dental Medicine, Nahda University Beni-Suef Egypt., Hafez HS; Deparment of Zoology, Faculty of Science, Suez University 43518 Suez Egypt hani.hafez@suezuniv.edu.eg Soha.Hassan@suezuniv.edu.eg., Elshaarawy RFM; Department of Chemistry, Faculty of Science, Suez University 43533 Suez Egypt reda.elshaarawy@suezuniv.edu.eg., Hassan SA; Deparment of Zoology, Faculty of Science, Suez University 43518 Suez Egypt hani.hafez@suezuniv.edu.eg Soha.Hassan@suezuniv.edu.eg.
Source: RSC advances [RSC Adv] 2026 Apr 16; Vol. 16 (22), pp. 19903-19919. Date of Electronic Publication: 2026 Apr 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of a multi-targeted sulfonyl-bridged bisselenadiazole derivative as a potent EGFR/PI3K/AKT/mTOR modulator in lung adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22El-Fattah+WA%22">El-Fattah WA</searchLink>; Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) P. O. Box 5701 Riyadh 11432 Saudi Arabia amalkasme@imamu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Guesmi+A%22">Guesmi A</searchLink>; Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) P. O. Box 5701 Riyadh 11432 Saudi Arabia amalkasme@imamu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Ben+Hamadi+N%22">Ben Hamadi N</searchLink>; Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) P. O. Box 5701 Riyadh 11432 Saudi Arabia amalkasme@imamu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Sayed+AR%22">Sayed AR</searchLink>; Institute of Basic and Applied Science, Egypt-Japan University of Science and Technology Alexandria Egypt abdelwahed.rashad@ejust.edu.eg.<br /><searchLink fieldCode="AU" term="%22El-Reedy+AAM%22">El-Reedy AAM</searchLink>; Basic-Applied Science Department, Faculty of Oral and Dental Medicine, Nahda University Beni-Suef Egypt.<br /><searchLink fieldCode="AU" term="%22Hafez+HS%22">Hafez HS</searchLink>; Deparment of Zoology, Faculty of Science, Suez University 43518 Suez Egypt hani.hafez@suezuniv.edu.eg Soha.Hassan@suezuniv.edu.eg.<br /><searchLink fieldCode="AU" term="%22Elshaarawy+RFM%22">Elshaarawy RFM</searchLink>; Department of Chemistry, Faculty of Science, Suez University 43533 Suez Egypt reda.elshaarawy@suezuniv.edu.eg.<br /><searchLink fieldCode="AU" term="%22Hassan+SA%22">Hassan SA</searchLink>; Deparment of Zoology, Faculty of Science, Suez University 43518 Suez Egypt hani.hafez@suezuniv.edu.eg Soha.Hassan@suezuniv.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%22101581657%22">RSC advances</searchLink> [RSC Adv] 2026 Apr 16; Vol. 16 (22), pp. 19903-19919. <i>Date of Electronic Publication: </i>2026 Apr 16 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101581657 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2046-2069 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220462069%22">20462069 </searchLink><i>NLM ISO Abbreviation: </i>RSC Adv <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42006818
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        Value: 10.1039/d6ra02006b
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      – Code: eng
        Text: English
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      – TitleFull: Development of a multi-targeted sulfonyl-bridged bisselenadiazole derivative as a potent EGFR/PI3K/AKT/mTOR modulator in lung adenocarcinoma.
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              Text: 2026 Apr 16
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              Y: 2026
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