Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function.

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Title: Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function.
Authors: Lio C; Faculty of Health Science, University of Macau, Taipa, Macau, China.; MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau, China., Wang Y; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Wilson PC; Department of Biological Sciences, Columbia University, New York, NY 10027, USA., Li Y; Faculty of Health Science, University of Macau, Taipa, Macau, China.; MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau, China., Antoku S; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Östlund C; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Shin JY; Department of Medicine, Columbia University, New York, NY 10032, USA., Worman HJ; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Chang W; Faculty of Health Science, University of Macau, Taipa, Macau, China.; MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau, China.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Gundersen GG; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Source: Journal of cell science [J Cell Sci] 2026 Jun 15; Vol. 139 (12). Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1477-9137
DOI:10.1242/jcs.264488