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Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function.

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Title: Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function.
Authors: Lio C; Faculty of Health Science, University of Macau, Taipa, Macau, China.; MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau, China., Wang Y; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Wilson PC; Department of Biological Sciences, Columbia University, New York, NY 10027, USA., Li Y; Faculty of Health Science, University of Macau, Taipa, Macau, China.; MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau, China., Antoku S; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Östlund C; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Shin JY; Department of Medicine, Columbia University, New York, NY 10032, USA., Worman HJ; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Chang W; Faculty of Health Science, University of Macau, Taipa, Macau, China.; MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau, China.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Gundersen GG; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Source: Journal of cell science [J Cell Sci] 2026 Jun 15; Vol. 139 (12). Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function.
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  Data: <searchLink fieldCode="AU" term="%22Lio+C%22">Lio C</searchLink>; Faculty of Health Science, University of Macau, Taipa, Macau, China.; MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+PC%22">Wilson PC</searchLink>; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Faculty of Health Science, University of Macau, Taipa, Macau, China.; MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau, China.<br /><searchLink fieldCode="AU" term="%22Antoku+S%22">Antoku S</searchLink>; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Östlund+C%22">Östlund C</searchLink>; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Shin+JY%22">Shin JY</searchLink>; Department of Medicine, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Worman+HJ%22">Worman HJ</searchLink>; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Chang+W%22">Chang W</searchLink>; Faculty of Health Science, University of Macau, Taipa, Macau, China.; MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau, China.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Gundersen+GG%22">Gundersen GG</searchLink>; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
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  Data: <searchLink fieldCode="JN" term="%220052457%22">Journal of cell science</searchLink> [J Cell Sci] 2026 Jun 15; Vol. 139 (12). <i>Date of Electronic Publication: </i>2026 May 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Company+of+Biologists%22">Company of Biologists </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0052457 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-9137 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219533%22">00219533 </searchLink><i>NLM ISO Abbreviation: </i>J Cell Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1242/jcs.264488
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        Text: English
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      – TitleFull: Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function.
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              Text: 2026 Jun 15
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