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Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca2+ influx.

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Title: Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca2+ influx.
Authors: Kaur K; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA., Alippe Y; Division of Rheumatology, Washington University School of Medicine, St. Louis MO 63110, USA., Wang C; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA., Semenkovich NP; Data Science Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Department of Medicine, Division of Endocrinology and Molecular Medicine, Milwaukee, WI 53226, USA., Hassan MG; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Bhagat S; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA., Khanna K; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA., Li Y; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA., Pokhrel N; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA., Peterson T; Healthspan Technologies Inc., St. Louis, MO 63110, USA., Scheller EL; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA., Veis DJ; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA., Abu-Amer Y; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Shriners Hospital for Children, St. Louis, MO 63110, USA., Faccio R; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA., Mbalaviele G; Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
Source: Science signaling [Sci Signal] 2026 Apr 21; Vol. 19 (934), pp. eaea2753. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1937-9145
DOI:10.1126/scisignal.aea2753