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Amivantamab Monotherapy in Chemorefractory RAS/BRAF Wild-Type Metastatic Colorectal Cancer: Results From OrigAMI-1, an Open-Label, Phase Ib/II Study.

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Title: Amivantamab Monotherapy in Chemorefractory RAS/BRAF Wild-Type Metastatic Colorectal Cancer: Results From OrigAMI-1, an Open-Label, Phase Ib/II Study.
Authors: Oberstein PE; NYU Langone Health, New York, NY., Hecht JR; UCLA Jonsson Comprehensive Cancer Center, Santa Monica, CA., Raghav K; MD Anderson Cancer Center, Houston, TX., Pietrantonio F; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Arnold D; Asklepios Tumorzentrum Hamburg, AK Altona, Hamburg, Germany., Moreno V; START Madrid-FJD, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain., Van Cutsem E; University of Leuven and University Hospitals Gasthuisberg, Leuven, Belgium., Malik RA; Department of Clinical Oncology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Hong YS; Asan Medical Center, Seoul, Republic of Korea., Lee MA; Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea., Yu-Li Su H; Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Lee J; Samsung Medical Center, Seoul, Republic of Korea., Chandana S; START Midwest, Grand Rapids, MI., Cruz-Correa M; University of Puerto Rico Comprehensive Cancer Center and Pan American Center for Oncology Trials, San Juan, Puerto Rico., Yuan Y; Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China., Ahmad A; Beacon Hospital, Petaling Jaya, Selangor, Malaysia., Lai KM; Changhua Christian Hospital, Changhua, Taiwan., Hsu HC; Division of Hematology-Oncology, Linkou Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan; School of Medicine, National Ching-Hua University, Hsinchu, Taiwan., Chen EX; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Elez E; Vall d'Hebron University Hospital, Barcelona, Spain., Lin CC; National Taiwan University Hospital, Taipei, Taiwan., Lopez C; Marqués de Valdecilla University Hospital, IDIVAL, UNICAN, Santander, Spain., Prenen H; Antwerp University Hospital, Edegem, Belgium., Roselló-Keränen S; Hospital Clínico Universitario, Valencia, Spain., Velez H; Ad-Vance Medical Research, Ponce, Puerto Rico., Yeh YM; National Cheng Kung University Hospital, Tainan, Taiwan., Heinemann V; Department of Hematology/Oncology, Ludwig-Maximilians-Universität Klinikum, University of Munich, Comprehensive Cancer Center Munich, Munich, Germany., Eng C; Vanderbilt-Ingram Cancer Center, Nashville, TN., Beom SH; Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea., Tejpar S; Department of Oncology, KU Leuven, Leuven, Belgium., Chowdhury S; Johnson & Johnson, Cambridge, MA., Lyu X; Johnson & Johnson, Shanghai, China., Kamat M; Johnson & Johnson, Spring House, PA., Curtin JC; Johnson & Johnson, Spring House, PA., Patel B; Johnson & Johnson, Spring House, PA., Xie J; Johnson & Johnson, Raritan, NJ., Bhattacharya R; Johnson & Johnson, Raritan, NJ., Schnepp RW; Johnson & Johnson, Spring House, PA., Yilmaz E; Johnson & Johnson, Raritan, NJ., Iwasawa R; Johnson & Johnson, Spring House, PA., Daksh M; Johnson & Johnson, Raritan, NJ., Lorenzini P; Johnson & Johnson, Raritan, NJ., Thayu M; Johnson & Johnson, Spring House, PA., Baig M; Johnson & Johnson, Raritan, NJ., Kim HS; Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea., Han SW; Seoul National University Hospital and Seoul National University Cancer Research Institute, Seoul, Republic of Korea.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2026 Jun 10; Vol. 44 (17), pp. 1624-1634. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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An: 42013403
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  Data: Amivantamab Monotherapy in Chemorefractory RAS/BRAF Wild-Type Metastatic Colorectal Cancer: Results From OrigAMI-1, an Open-Label, Phase Ib/II Study.
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Department of Clinical Oncology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Hong+YS%22">Hong YS</searchLink>; Asan Medical Center, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+MA%22">Lee MA</searchLink>; Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yu-Li+Su+H%22">Yu-Li Su H</searchLink>; Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Samsung Medical Center, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chandana+S%22">Chandana S</searchLink>; START Midwest, Grand Rapids, MI.<br /><searchLink fieldCode="AU" term="%22Cruz-Correa+M%22">Cruz-Correa M</searchLink>; University of Puerto Rico Comprehensive Cancer Center and Pan American Center for Oncology Trials, San Juan, Puerto Rico.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2026 Jun 10; Vol. 44 (17), pp. 1624-1634. <i>Date of Electronic Publication: </i>2026 Apr 21.
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