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Evolving landscape of targeted therapies in early phase clinical trials.

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Title: Evolving landscape of targeted therapies in early phase clinical trials.
Authors: Rossi A; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Braña I; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Vieito M; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Mirallas O; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Navarro V; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Saavedra O; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Casal GA; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Galvao V; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Bardaji MJL; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Oberoi A; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Pretelli G; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Sanz M; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Bueno SA; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Abril BF; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Izquierdo SA; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Jimenez J; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Nuciforo P; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Vivancos A; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Oliveira M; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Baraibar I; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Castet F; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Duran CG; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Ahnert JR; Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Capdevila J; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Galceran JC; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Macarulla T; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Saura C; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Felip E; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Elez E; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Tabernero J; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Dienstmann R; Vall d´Hebron Institute of Oncology, Barcelona, Spain; University of Vic - Central University of Catalonia, Vic, Spain., Villacampa G; Vall d´Hebron Institute of Oncology, Barcelona, Spain., Garralda E; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain., Hernando-Calvo A; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain. Electronic address: albertohernando@vhio.net.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Jun 03; Vol. 240, pp. 116745. Date of Electronic Publication: 2026 Apr 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Evolving landscape of targeted therapies in early phase clinical trials.
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  Data: <searchLink fieldCode="AU" term="%22Rossi+A%22">Rossi A</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Braña+I%22">Braña I</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vieito+M%22">Vieito M</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Mirallas+O%22">Mirallas O</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Navarro+V%22">Navarro V</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Saavedra+O%22">Saavedra O</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Casal+GA%22">Casal GA</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Galvao+V%22">Galvao V</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bardaji+MJL%22">Bardaji MJL</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Oberoi+A%22">Oberoi A</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pretelli+G%22">Pretelli G</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+M%22">Sanz M</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bueno+SA%22">Bueno SA</searchLink>; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Abril+BF%22">Abril BF</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Izquierdo+SA%22">Izquierdo SA</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Jimenez+J%22">Jimenez J</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Nuciforo+P%22">Nuciforo P</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vivancos+A%22">Vivancos A</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Oliveira+M%22">Oliveira M</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Baraibar+I%22">Baraibar I</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Castet+F%22">Castet F</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Duran+CG%22">Duran CG</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ahnert+JR%22">Ahnert JR</searchLink>; Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Capdevila+J%22">Capdevila J</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Galceran+JC%22">Galceran JC</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Macarulla+T%22">Macarulla T</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Saura+C%22">Saura C</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Felip+E%22">Felip E</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Elez+E%22">Elez E</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tabernero+J%22">Tabernero J</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Dienstmann+R%22">Dienstmann R</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; University of Vic - Central University of Catalonia, Vic, Spain.<br /><searchLink fieldCode="AU" term="%22Villacampa+G%22">Villacampa G</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Garralda+E%22">Garralda E</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hernando-Calvo+A%22">Hernando-Calvo A</searchLink>; Vall d´Hebron Institute of Oncology, Barcelona, Spain; Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, IIS IR-HUVH, Barcelona, Spain. Electronic address: albertohernando@vhio.net.
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