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Design, synthesis and anti-bladder cancer activity of novel dihydroartemisinin-ibuprofen hybrids.

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Title: Design, synthesis and anti-bladder cancer activity of novel dihydroartemisinin-ibuprofen hybrids.
Authors: Yu H; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center for TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., Liu D; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., Xu J; Department of General Surgery, Shanghai Pudong New Area Gongli Hospital, 219 MiaoPu Road, Shanghai 200135, China., Li A; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., Yan X; College of Mathematics and Physics, Shanghai University of Electric Power, 1851 Huchenghuan Road, Shanghai 200090, China., Bejoma T; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center for TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., Li Y; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., Yang J; Department of HepatoBiliary Surgery, the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Shanghai 200137, China. Electronic address: yjmorphine@163.com., Peng P; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address: pengpeike@shutcm.edu.cn., Zhao Q; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center for TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address: zhaoqingjie@shutcm.edu.cn.
Source: Bioorganic chemistry [Bioorg Chem] 2026 Jul 15; Vol. 176, pp. 109893. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, synthesis and anti-bladder cancer activity of novel dihydroartemisinin-ibuprofen hybrids.
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  Data: <searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center for TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of General Surgery, Shanghai Pudong New Area Gongli Hospital, 219 MiaoPu Road, Shanghai 200135, China.<br /><searchLink fieldCode="AU" term="%22Li+A%22">Li A</searchLink>; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Yan+X%22">Yan X</searchLink>; College of Mathematics and Physics, Shanghai University of Electric Power, 1851 Huchenghuan Road, Shanghai 200090, China.<br /><searchLink fieldCode="AU" term="%22Bejoma+T%22">Bejoma T</searchLink>; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center for TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of HepatoBiliary Surgery, the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Shanghai 200137, China. Electronic address: yjmorphine@163.com.<br /><searchLink fieldCode="AU" term="%22Peng+P%22">Peng P</searchLink>; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address: pengpeike@shutcm.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center for TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address: zhaoqingjie@shutcm.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2026 Jul 15; Vol. 176, pp. 109893. <i>Date of Electronic Publication: </i>2026 Apr 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bioorg.2026.109893
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        Text: English
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              Text: 2026 Jul 15
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