A framework for the exploration of subcellular compartmentalization of RNA-binding proteins.

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Title: A framework for the exploration of subcellular compartmentalization of RNA-binding proteins.
Authors: Guo X; The Fifth Affiliated Hospital of Guangzhou Medical University-BGI Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; 3DC STAR Lab, BGI CELL, Shenzhen, China.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China., Hu J; Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Kanwal S; Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China., Yuan J; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Tariq M; Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China., Zheng J; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China., Sun M; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China., Lu Y; Institutes of Physical Science and Information Technology, Anhui University, Hefei, China., Wang J; GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, China., Jiang M; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Wang A; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Castells-Garcia A; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Zheng X; Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China., Peng B; Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China., Wang D; Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China., Wei X; China National GeneBank, BGI Research, Shenzhen, China., Yang T; China National GeneBank, BGI Research, Shenzhen, China., Volpe G; Hematology and Cell Therapy Unit, IRCCS-Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Wu L; 3DC STAR Lab, BGI CELL, Shenzhen, China.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China., Mazid MA; Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China., Li W; Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China., Lai Y; The Fifth Affiliated Hospital of Guangzhou Medical University-BGI Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.; Shanxi Medical University-BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan, China., Qin D; Guangdong Engineering Technology Research Center of Biological Targeting Diagnosis, Therapy and Rehabilitation, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.; Guangdong Engineering Research Center of Early Clinical Trials of Biotechnology Drugs, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong SAR, China., Aguilo F; Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden., Zhou Y; College of Life Sciences, TaiKang Center for Life and Medical Sciences, RNA Institute, Wuhan University, Wuhan, China., Liu C; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China.; Shanxi Medical University-BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan, China.; Shenzhen Proof-of-Concept Center of Digital Cytopathology, BGI Research, Shenzhen, China., Cosma MP; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.; ICREA, Barcelona, Spain., Xu X; Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China., Lundberg E; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH-Royal Institute of Technology, Stockholm, Sweden.; Department of Bioengineering, Stanford University, Stanford, CA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA., Mulder J; Science for Life Laboratory, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.; Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology, Stockholm, Sweden., Hutchins AP; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China., Maxwell PH; School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Di Croce L; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; ICREA, Barcelona, Spain., Zhang X; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. zhang_xiaofei@gibh.ac.cn., Esteban MA; The Fifth Affiliated Hospital of Guangzhou Medical University-BGI Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. miguelesteban@genomics.cn.; 3DC STAR Lab, BGI CELL, Shenzhen, China. miguelesteban@genomics.cn.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China. miguelesteban@genomics.cn.; Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China. miguelesteban@genomics.cn.; Prince Fahad bin Sultan Research Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia. miguelesteban@genomics.cn., Lv Y; 3DC STAR Lab, BGI CELL, Shenzhen, China. lvyuan@genomics.cn.; Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China. lvyuan@genomics.cn.; Shanxi Medical University-BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan, China. lvyuan@genomics.cn.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China. lvyuan@genomics.cn.
Source: Nature communications [Nat Commun] 2026 Apr 21; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-71511-y