NirFAP680: a highly bright and stable large Stokes shift near-infrared fluorogen-activating protein.

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Title: NirFAP680: a highly bright and stable large Stokes shift near-infrared fluorogen-activating protein.
Authors: Chen Z; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Jiang L; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Liu X; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Shi Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Liu Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Jiang L; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Li J; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Huang X; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Zhou S; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Bao B; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Zhang B; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Lin Q; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Bian Q; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Yin Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Zuo F; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Su N; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China., Tang Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Zhao Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Yang Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China. yiyang@ecust.edu.cn.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. yiyang@ecust.edu.cn., Chen X; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China. xianjunchen@ecust.edu.cn., Zhu L; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. linyongzhu@sjtu.edu.cn.
Source: Nature methods [Nat Methods] 2026 May; Vol. 23 (5), pp. 960-971. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101215604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-7105 (Electronic) Linking ISSN: 15487091 NLM ISO Abbreviation: Nat Methods Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1548-7105
DOI:10.1038/s41592-026-03061-6