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NirFAP680: a highly bright and stable large Stokes shift near-infrared fluorogen-activating protein.

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Title: NirFAP680: a highly bright and stable large Stokes shift near-infrared fluorogen-activating protein.
Authors: Chen Z; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Jiang L; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Liu X; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Shi Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Liu Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Jiang L; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Li J; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Huang X; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Zhou S; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Bao B; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Zhang B; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Lin Q; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Bian Q; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Yin Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Zuo F; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Su N; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China., Tang Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Zhao Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Yang Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China. yiyang@ecust.edu.cn.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. yiyang@ecust.edu.cn., Chen X; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China. xianjunchen@ecust.edu.cn., Zhu L; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. linyongzhu@sjtu.edu.cn.
Source: Nature methods [Nat Methods] 2026 May; Vol. 23 (5), pp. 960-971. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101215604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-7105 (Electronic) Linking ISSN: 15487091 NLM ISO Abbreviation: Nat Methods Subsets: MEDLINE
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  Data: NirFAP680: a highly bright and stable large Stokes shift near-infrared fluorogen-activating protein.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhou+S%22">Zhou S</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Bao+B%22">Bao B</searchLink>; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lin+Q%22">Lin Q</searchLink>; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Bian+Q%22">Bian Q</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yin+Y%22">Yin Y</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zuo+F%22">Zuo F</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Su+N%22">Su N</searchLink>; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China. yiyang@ecust.edu.cn.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. yiyang@ecust.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China. xianjunchen@ecust.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. linyongzhu@sjtu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101215604%22">Nature methods</searchLink> [Nat Methods] 2026 May; Vol. 23 (5), pp. 960-971. <i>Date of Electronic Publication: </i>2026 Apr 21.
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