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Comparative genomics identifies small interfering RNA with activity against all five human betacoronaviruses.

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Title: Comparative genomics identifies small interfering RNA with activity against all five human betacoronaviruses.
Authors: Vogler J; Institute of Laboratory Medicine, LMU University Hospital, LMU Munich, Munich, Germany., Ambike S; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany.; Current affiliation: Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Velkov S; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany., Cheng CC; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany., Neubecker P; Institute of Virology, Philipps University Marburg, Marburg, Germany., Fischhaber N; Institute of Laboratory Medicine, LMU University Hospital, LMU Munich, Munich, Germany., Mallick P; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany., Martan I; Institute of Laboratory Medicine, LMU University Hospital, LMU Munich, Munich, Germany., Sauerhering L; Institute of Virology, Philipps University Marburg, Marburg, Germany., von Brunn A; Max von Pettenkofer Institute and Gene Center, LMU Munich, Virology, Munich, Germany.; German Center for Infection Research (DZIF), Munich partner site, Munich, Germany., Protzer U; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany.; German Center for Infection Research (DZIF), Munich partner site, Munich, Germany., Michler T; Institute of Laboratory Medicine, LMU University Hospital, LMU Munich, Munich, Germany. thomas.michler@med.uni-muenchen.de.; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany. thomas.michler@med.uni-muenchen.de.
Source: Genome medicine [Genome Med] 2026 Apr 22; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article; Comparative Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
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  Data: Comparative genomics identifies small interfering RNA with activity against all five human betacoronaviruses.
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  Data: <searchLink fieldCode="AU" term="%22Vogler+J%22">Vogler J</searchLink>; Institute of Laboratory Medicine, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ambike+S%22">Ambike S</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany.; Current affiliation: Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Velkov+S%22">Velkov S</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Cheng+CC%22">Cheng CC</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Neubecker+P%22">Neubecker P</searchLink>; Institute of Virology, Philipps University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fischhaber+N%22">Fischhaber N</searchLink>; Institute of Laboratory Medicine, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mallick+P%22">Mallick P</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Martan+I%22">Martan I</searchLink>; Institute of Laboratory Medicine, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sauerhering+L%22">Sauerhering L</searchLink>; Institute of Virology, Philipps University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22von+Brunn+A%22">von Brunn A</searchLink>; Max von Pettenkofer Institute and Gene Center, LMU Munich, Virology, Munich, Germany.; German Center for Infection Research (DZIF), Munich partner site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Protzer+U%22">Protzer U</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany.; German Center for Infection Research (DZIF), Munich partner site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Michler+T%22">Michler T</searchLink>; Institute of Laboratory Medicine, LMU University Hospital, LMU Munich, Munich, Germany. thomas.michler@med.uni-muenchen.de.; Institute of Virology, School of Medicine and Health, Technical University of Munich, Helmholtz Munich, Munich, Germany. thomas.michler@med.uni-muenchen.de.
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  Data: <searchLink fieldCode="JN" term="%22101475844%22">Genome medicine</searchLink> [Genome Med] 2026 Apr 22; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 Apr 22.
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