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Biofilm- and Spore-Disruptive Star-Shaped Poly(l-lysine)/Hyaluronic Acid Microgels for Targeted Oral Therapy of Clostridioides difficile Infection.

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Title: Biofilm- and Spore-Disruptive Star-Shaped Poly(l-lysine)/Hyaluronic Acid Microgels for Targeted Oral Therapy of Clostridioides difficile Infection.
Authors: Lin IF; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445, Taiwan.; School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan., Chou CY; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan., Chen YF; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan., Wang TY; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan., Lin JT; Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan., Lee CC; Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 70403, Taiwan.; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan., Chen JW; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan., Jan JS; Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.; Program on Smart and Sustainable Manufacturing, Academy of Innovative Semiconductor and Sustainable Manufacturing, National Cheng Kung University, Tainan 70101, Taiwan., Hung YP; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 70403, Taiwan.; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Department of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan 70043, Taiwan.
Source: Biomacromolecules [Biomacromolecules] 2026 May 11; Vol. 27 (5), pp. 3019-3032. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE
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  Data: Biofilm- and Spore-Disruptive Star-Shaped Poly(l-lysine)/Hyaluronic Acid Microgels for Targeted Oral Therapy of Clostridioides difficile Infection.
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  Data: <searchLink fieldCode="AU" term="%22Lin+IF%22">Lin IF</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445, Taiwan.; School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chou+CY%22">Chou CY</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YF%22">Chen YF</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+TY%22">Wang TY</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+JT%22">Lin JT</searchLink>; Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+CC%22">Lee CC</searchLink>; Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 70403, Taiwan.; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JW%22">Chen JW</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jan+JS%22">Jan JS</searchLink>; Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.; Program on Smart and Sustainable Manufacturing, Academy of Innovative Semiconductor and Sustainable Manufacturing, National Cheng Kung University, Tainan 70101, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+YP%22">Hung YP</searchLink>; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 70403, Taiwan.; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Department of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan 70043, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22100892849%22">Biomacromolecules</searchLink> [Biomacromolecules] 2026 May 11; Vol. 27 (5), pp. 3019-3032. <i>Date of Electronic Publication: </i>2026 Apr 22.
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        Value: 10.1021/acs.biomac.5c02037
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              Text: 2026 May 11
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