Structure-based design of potent pyrazolo[1,5-a]pyrimidine CDK4/6 inhibitors: biological evaluation and computational validation.
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| Title: | Structure-based design of potent pyrazolo[1,5-a]pyrimidine CDK4/6 inhibitors: biological evaluation and computational validation. |
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| Authors: | Binjubair FA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia., Elkotamy MS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alsalam University Kafr Alzayat 31611, Algharbia Egypt mahmoudelkotami@gmail.com., Mattar AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, El Saleheya El Gadida University Egypt., Almutairy BK; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University Al-Kharj Saudi Arabia., Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia., Eldesouki MM; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt., Bouajila J; Laboratoire de Génie Chimique, Université de Toulouse, Toulouse INP, CNRS, LGC Toulouse France., Abdel-Aziz HA; Applied Organic Chemistry Department, National Research Centre Dokki Cairo 12622 Egypt., Fakhry MM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University Badr City Cairo 11829 Egypt mariam-medhat@eru.edu.eg. |
| Source: | RSC medicinal chemistry [RSC Med Chem] 2026 Apr 20. Date of Electronic Publication: 2026 Apr 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42016581 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Structure-based design of potent pyrazolo[1,5-a]pyrimidine CDK4/6 inhibitors: biological evaluation and computational validation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Binjubair+FA%22">Binjubair FA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elkotamy+MS%22">Elkotamy MS</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alsalam University Kafr Alzayat 31611, Algharbia Egypt mahmoudelkotami@gmail.com.<br /><searchLink fieldCode="AU" term="%22Mattar+AA%22">Mattar AA</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, El Saleheya El Gadida University Egypt.<br /><searchLink fieldCode="AU" term="%22Almutairy+BK%22">Almutairy BK</searchLink>; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University Al-Kharj Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al-Rashood+ST%22">Al-Rashood ST</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Eldesouki+MM%22">Eldesouki MM</searchLink>; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt.<br /><searchLink fieldCode="AU" term="%22Bouajila+J%22">Bouajila J</searchLink>; Laboratoire de Génie Chimique, Université de Toulouse, Toulouse INP, CNRS, LGC Toulouse France.<br /><searchLink fieldCode="AU" term="%22Abdel-Aziz+HA%22">Abdel-Aziz HA</searchLink>; Applied Organic Chemistry Department, National Research Centre Dokki Cairo 12622 Egypt.<br /><searchLink fieldCode="AU" term="%22Fakhry+MM%22">Fakhry MM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University Badr City Cairo 11829 Egypt mariam-medhat@eru.edu.eg. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101759460%22">RSC medicinal chemistry</searchLink> [RSC Med Chem] 2026 Apr 20. <i>Date of Electronic Publication: </i>2026 Apr 20. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101759460 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2632-8682 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226328682%22">26328682 </searchLink><i>NLM ISO Abbreviation: </i>RSC Med Chem |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42016581 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1039/d5md01147g Languages: – Code: eng Text: English Titles: – TitleFull: Structure-based design of potent pyrazolo[1,5-a]pyrimidine CDK4/6 inhibitors: biological evaluation and computational validation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Binjubair FA – PersonEntity: Name: NameFull: Elkotamy MS – PersonEntity: Name: NameFull: Mattar AA – PersonEntity: Name: NameFull: Almutairy BK – PersonEntity: Name: NameFull: Al-Rashood ST – PersonEntity: Name: NameFull: Eldesouki MM – PersonEntity: Name: NameFull: Bouajila J – PersonEntity: Name: NameFull: Abdel-Aziz HA – PersonEntity: Name: NameFull: Fakhry MM IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 04 Text: 2026 Apr 20 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2632-8682 Titles: – TitleFull: RSC medicinal chemistry Type: main |
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