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Targeting CRTC2 reverses STK11 mutant NSCLC tumor resistance to immunotherapy.

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Bibliographic Details
Title: Targeting CRTC2 reverses STK11 mutant NSCLC tumor resistance to immunotherapy.
Authors: Robay D; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Ackermann O; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Laborde L; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Shi X; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Oreglia F; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Stump R; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Ciaghi S; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Galli GG; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Holzer L; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Villemin L; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Wagner J; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Wu J; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Lee LH; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Bossen C; Novartis Pharma, Basel 4056, Switzerland., Mourikis TP; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Gabriel M; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Ruddy D; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Yu H; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Johannessen C; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Ferretti S; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Costa C; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 28; Vol. 123 (17), pp. e2508762123. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2508762123