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Targeting CRTC2 reverses STK11 mutant NSCLC tumor resistance to immunotherapy.

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Title: Targeting CRTC2 reverses STK11 mutant NSCLC tumor resistance to immunotherapy.
Authors: Robay D; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Ackermann O; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Laborde L; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Shi X; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Oreglia F; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Stump R; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Ciaghi S; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Galli GG; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Holzer L; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Villemin L; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Wagner J; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Wu J; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Lee LH; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Bossen C; Novartis Pharma, Basel 4056, Switzerland., Mourikis TP; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Gabriel M; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Ruddy D; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Yu H; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Johannessen C; Novartis Biomedical Research, Oncology, Cambridge, MA 02139., Ferretti S; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland., Costa C; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 28; Vol. 123 (17), pp. e2508762123. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Targeting CRTC2 reverses STK11 mutant NSCLC tumor resistance to immunotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Robay+D%22">Robay D</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ackermann+O%22">Ackermann O</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Laborde+L%22">Laborde L</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Shi+X%22">Shi X</searchLink>; Novartis Biomedical Research, Oncology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Oreglia+F%22">Oreglia F</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stump+R%22">Stump R</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ciaghi+S%22">Ciaghi S</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Galli+GG%22">Galli GG</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Holzer+L%22">Holzer L</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Villemin+L%22">Villemin L</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wagner+J%22">Wagner J</searchLink>; Novartis Biomedical Research, Oncology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Novartis Biomedical Research, Oncology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Lee+LH%22">Lee LH</searchLink>; Novartis Biomedical Research, Oncology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Bossen+C%22">Bossen C</searchLink>; Novartis Pharma, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mourikis+TP%22">Mourikis TP</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gabriel+M%22">Gabriel M</searchLink>; Novartis Biomedical Research, Oncology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Ruddy+D%22">Ruddy D</searchLink>; Novartis Biomedical Research, Oncology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Novartis Biomedical Research, Oncology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Johannessen+C%22">Johannessen C</searchLink>; Novartis Biomedical Research, Oncology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Ferretti+S%22">Ferretti S</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Costa+C%22">Costa C</searchLink>; Novartis Biomedical Research, Oncology, Basel 4056, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Apr 28; Vol. 123 (17), pp. e2508762123. <i>Date of Electronic Publication: </i>2026 Apr 22.
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