Ordinal GWAS analysis of the frailty phenotype identified a novel locus at 12q22 that underscores the role of the neurological and immune systems.

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Title: Ordinal GWAS analysis of the frailty phenotype identified a novel locus at 12q22 that underscores the role of the neurological and immune systems.
Authors: Borhan S; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. borhana@mcmaster.ca.; Research Methodology Centre, Research Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada. borhana@mcmaster.ca.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada. borhana@mcmaster.ca., An Nguyen LM; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Pigeyre M; Department of Medicine, McMaster University, Hamilton, ON, Canada., Pare G; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Adachi J; Department of Medicine, McMaster University, Hamilton, ON, Canada., Papaioannou A; Department of Medicine, McMaster University, Hamilton, ON, Canada.; GERAS Centre for Aging Research, Hamilton, ON, Canada., Griffith LE; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada., Thabane L; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Research Methodology Centre, Research Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada., Raina P; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada.
Source: Npj aging [NPJ Aging] 2026 Apr 22; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918402285106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-6068 (Electronic) Linking ISSN: 27316068 NLM ISO Abbreviation: NPJ Aging Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2731-6068
DOI:10.1038/s41514-026-00363-z