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Ordinal GWAS analysis of the frailty phenotype identified a novel locus at 12q22 that underscores the role of the neurological and immune systems.

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Title: Ordinal GWAS analysis of the frailty phenotype identified a novel locus at 12q22 that underscores the role of the neurological and immune systems.
Authors: Borhan S; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. borhana@mcmaster.ca.; Research Methodology Centre, Research Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada. borhana@mcmaster.ca.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada. borhana@mcmaster.ca., An Nguyen LM; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Pigeyre M; Department of Medicine, McMaster University, Hamilton, ON, Canada., Pare G; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Adachi J; Department of Medicine, McMaster University, Hamilton, ON, Canada., Papaioannou A; Department of Medicine, McMaster University, Hamilton, ON, Canada.; GERAS Centre for Aging Research, Hamilton, ON, Canada., Griffith LE; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada., Thabane L; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Research Methodology Centre, Research Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada., Raina P; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada.
Source: Npj aging [NPJ Aging] 2026 Apr 22; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918402285106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-6068 (Electronic) Linking ISSN: 27316068 NLM ISO Abbreviation: NPJ Aging Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Ordinal GWAS analysis of the frailty phenotype identified a novel locus at 12q22 that underscores the role of the neurological and immune systems.
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  Data: <searchLink fieldCode="AU" term="%22Borhan+S%22">Borhan S</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. borhana@mcmaster.ca.; Research Methodology Centre, Research Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada. borhana@mcmaster.ca.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada. borhana@mcmaster.ca.<br /><searchLink fieldCode="AU" term="%22An+Nguyen+LM%22">An Nguyen LM</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pigeyre+M%22">Pigeyre M</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pare+G%22">Pare G</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Adachi+J%22">Adachi J</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Papaioannou+A%22">Papaioannou A</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada.; GERAS Centre for Aging Research, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Griffith+LE%22">Griffith LE</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Thabane+L%22">Thabane L</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Research Methodology Centre, Research Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Raina+P%22">Raina P</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; McMaster Institute for Research on Aging (MIRA), McMaster University, Hamilton, ON, Canada.
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  Data: <searchLink fieldCode="JN" term="%229918402285106676%22">Npj aging</searchLink> [NPJ Aging] 2026 Apr 22; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Apr 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918402285106676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2731-6068 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227316068%22">27316068 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Aging <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41514-026-00363-z
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              Text: 2026 Apr 22
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