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Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice.

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Title: Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice.
Authors: Koutsoumpou X; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium., Lenders V; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium., Krishnamoorthy AL; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium., Vlaeminck I; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium., Rozenski J; Medicinal Chemistry, Rega Institute for Medical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, B3000, Leuven, Belgium., De Marco F; Medicinal Chemistry, Rega Institute for Medical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, B3000, Leuven, Belgium., Luci CR; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium., Goncalves FR; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium., Girmatsion H; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium., Ciwinksa M; Laboratory of Intravital Microscopy and Dynamics of Tumor Progression, VIB Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium., Nobis M; Intravital Imaging Expertise Center, VIB Center for Cancer Biology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium., Scheele CLGJ; Laboratory of Intravital Microscopy and Dynamics of Tumor Progression, VIB Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium., Soenen SJ; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium., De Vleeschouwer S; Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.; Laboratory of Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium., Manshian BB; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium. bella.manshian@kuleuven.be.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium. bella.manshian@kuleuven.be.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Apr 22; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
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  Data: Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice.
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  Data: <searchLink fieldCode="AU" term="%22Koutsoumpou+X%22">Koutsoumpou X</searchLink>; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Lenders+V%22">Lenders V</searchLink>; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Krishnamoorthy+AL%22">Krishnamoorthy AL</searchLink>; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vlaeminck+I%22">Vlaeminck I</searchLink>; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Rozenski+J%22">Rozenski J</searchLink>; Medicinal Chemistry, Rega Institute for Medical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Marco+F%22">De Marco F</searchLink>; Medicinal Chemistry, Rega Institute for Medical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Luci+CR%22">Luci CR</searchLink>; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Goncalves+FR%22">Goncalves FR</searchLink>; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Girmatsion+H%22">Girmatsion H</searchLink>; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Ciwinksa+M%22">Ciwinksa M</searchLink>; Laboratory of Intravital Microscopy and Dynamics of Tumor Progression, VIB Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Nobis+M%22">Nobis M</searchLink>; Intravital Imaging Expertise Center, VIB Center for Cancer Biology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Scheele+CLGJ%22">Scheele CLGJ</searchLink>; Laboratory of Intravital Microscopy and Dynamics of Tumor Progression, VIB Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Soenen+SJ%22">Soenen SJ</searchLink>; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Vleeschouwer+S%22">De Vleeschouwer S</searchLink>; Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.; Laboratory of Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Manshian+BB%22">Manshian BB</searchLink>; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium. bella.manshian@kuleuven.be.; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000, Leuven, Belgium. bella.manshian@kuleuven.be.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2026 Apr 22; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Apr 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101152208 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-3155 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214773155%22">14773155 </searchLink><i>NLM ISO Abbreviation: </i>J Nanobiotechnology <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12951-026-04350-0
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        Text: English
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      – TitleFull: Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice.
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              Text: 2026 Apr 22
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