Diagnostic performance of β-(1→3)-D-glucan, two Candida antigen, and five anti-Candida antibody assays in ICU patients with sepsis and high risk for invasive candidiasis: a secondary endpoint of the CandiSep randomized clinical trial.

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Title: Diagnostic performance of β-(1→3)-D-glucan, two Candida antigen, and five anti-Candida antibody assays in ICU patients with sepsis and high risk for invasive candidiasis: a secondary endpoint of the CandiSep randomized clinical trial.
Authors: Standl L; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany., Huber T; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany.; Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany., Bloos F; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Thomas-Rüddel D; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA., Träger J; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany., Kluge S; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Fichtner F; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany., Simon P; Anesthesiology and Operative Intensive Care, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Kogelmann K; Department of Anaesthesiology, Klinikum Leer, Leer, Germany., de Heer G; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Kuhn S; Department of Anesthesiology and Intensive Care Medicine, University Hospital Greifswald, Greifswald, Germany., Jarczak D; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Motsch J; Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany., Hempel G; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany., Weiler N; Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Weyland A; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany., Drüner M; Department of Anesthesiology and Intensive Care Medicine, Hospital Emden, Emden, Germany., Gründling M; Department of Anesthesiology and Intensive Care Medicine, University Hospital Greifswald, Greifswald, Germany., Meybohm P; Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany., Richter D; Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany., Moerer O; Department of Anesthesiology, University Medical Center, Georg-August-University, Göttingen, Germany., Günther U; University Clinic of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Klinikum Oldenburg, Oldenburg, Germany.; Department Of Adult Intensive Care, University Medical Center Groningen, Groningen, the Netherlands., Schädler D; Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Zarbock A; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Putensen C; Division of Intensive Care Medicine, Dept. of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Castellanos I; Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany., Kurzai O; Institute for Hygiene and Microbiology, Julius Maximilians University Würzburg, Würzburg, Germany.; National Reference Center for Invasive Fungal Infections NRZMyk, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, Jena, Germany., Schlattmann P; Computer Sciences and Data Science, Institute of Medical Statistics, Jena University Hospital, Jena, Germany., Cornely OA; Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Translational Research, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Bauer M; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Lehmann T; Center for Clinical Studies, Jena University Hospital, Jena, Germany., Valenza G; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany., Bogdan C; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany.; FAU Profile Center for Immunomedicine, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany., Held J; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany.
Corporate Authors: SepNet Critical Care Trials Group
Source: Journal of clinical microbiology [J Clin Microbiol] 2026 May 13; Vol. 64 (5), pp. e0150025. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Evaluation Study
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7505564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-660X (Electronic) Linking ISSN: 00951137 NLM ISO Abbreviation: J Clin Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1098-660X
DOI:10.1128/jcm.01500-25