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Diagnostic performance of β-(1→3)-D-glucan, two Candida antigen, and five anti-Candida antibody assays in ICU patients with sepsis and high risk for invasive candidiasis: a secondary endpoint of the CandiSep randomized clinical trial.

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Title: Diagnostic performance of β-(1→3)-D-glucan, two Candida antigen, and five anti-Candida antibody assays in ICU patients with sepsis and high risk for invasive candidiasis: a secondary endpoint of the CandiSep randomized clinical trial.
Authors: Standl L; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany., Huber T; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany.; Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany., Bloos F; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Thomas-Rüddel D; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA., Träger J; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany., Kluge S; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Fichtner F; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany., Simon P; Anesthesiology and Operative Intensive Care, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Kogelmann K; Department of Anaesthesiology, Klinikum Leer, Leer, Germany., de Heer G; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Kuhn S; Department of Anesthesiology and Intensive Care Medicine, University Hospital Greifswald, Greifswald, Germany., Jarczak D; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Motsch J; Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany., Hempel G; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany., Weiler N; Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Weyland A; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany., Drüner M; Department of Anesthesiology and Intensive Care Medicine, Hospital Emden, Emden, Germany., Gründling M; Department of Anesthesiology and Intensive Care Medicine, University Hospital Greifswald, Greifswald, Germany., Meybohm P; Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany., Richter D; Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany., Moerer O; Department of Anesthesiology, University Medical Center, Georg-August-University, Göttingen, Germany., Günther U; University Clinic of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Klinikum Oldenburg, Oldenburg, Germany.; Department Of Adult Intensive Care, University Medical Center Groningen, Groningen, the Netherlands., Schädler D; Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Zarbock A; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Putensen C; Division of Intensive Care Medicine, Dept. of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Castellanos I; Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany., Kurzai O; Institute for Hygiene and Microbiology, Julius Maximilians University Würzburg, Würzburg, Germany.; National Reference Center for Invasive Fungal Infections NRZMyk, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, Jena, Germany., Schlattmann P; Computer Sciences and Data Science, Institute of Medical Statistics, Jena University Hospital, Jena, Germany., Cornely OA; Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Translational Research, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Bauer M; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Lehmann T; Center for Clinical Studies, Jena University Hospital, Jena, Germany., Valenza G; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany., Bogdan C; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany.; FAU Profile Center for Immunomedicine, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany., Held J; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany.
Corporate Authors: SepNet Critical Care Trials Group
Source: Journal of clinical microbiology [J Clin Microbiol] 2026 May 13; Vol. 64 (5), pp. e0150025. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Evaluation Study
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7505564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-660X (Electronic) Linking ISSN: 00951137 NLM ISO Abbreviation: J Clin Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Diagnostic performance of β-(1→3)-D-glucan, two Candida antigen, and five anti-Candida antibody assays in ICU patients with sepsis and high risk for invasive candidiasis: a secondary endpoint of the CandiSep randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Standl+L%22">Standl L</searchLink>; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Huber+T%22">Huber T</searchLink>; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany.; Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Bloos+F%22">Bloos F</searchLink>; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Thomas-Rüddel+D%22">Thomas-Rüddel D</searchLink>; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Träger+J%22">Träger J</searchLink>; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kluge+S%22">Kluge S</searchLink>; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fichtner+F%22">Fichtner F</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Simon+P%22">Simon P</searchLink>; Anesthesiology and Operative Intensive Care, Faculty of Medicine, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kogelmann+K%22">Kogelmann K</searchLink>; Department of Anaesthesiology, Klinikum Leer, Leer, Germany.<br /><searchLink fieldCode="AU" term="%22de+Heer+G%22">de Heer G</searchLink>; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kuhn+S%22">Kuhn S</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Jarczak+D%22">Jarczak D</searchLink>; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Motsch+J%22">Motsch J</searchLink>; Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hempel+G%22">Hempel G</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Weiler+N%22">Weiler N</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Weyland+A%22">Weyland A</searchLink>; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Drüner+M%22">Drüner M</searchLink>; 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Department Of Adult Intensive Care, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schädler+D%22">Schädler D</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Zarbock+A%22">Zarbock A</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Putensen+C%22">Putensen C</searchLink>; Division of Intensive Care Medicine, Dept. of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Castellanos+I%22">Castellanos I</searchLink>; Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kurzai+O%22">Kurzai O</searchLink>; Institute for Hygiene and Microbiology, Julius Maximilians University Würzburg, Würzburg, Germany.; National Reference Center for Invasive Fungal Infections NRZMyk, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Schlattmann+P%22">Schlattmann P</searchLink>; Computer Sciences and Data Science, Institute of Medical Statistics, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Cornely+OA%22">Cornely OA</searchLink>; Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Translational Research, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+M%22">Bauer M</searchLink>; 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