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Apelin-13 alleviates post-infarction injury by modulating macrophage inflammation via APJ-dependent inhibition of NLRP3-mediated pyroptosis.

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Title: Apelin-13 alleviates post-infarction injury by modulating macrophage inflammation via APJ-dependent inhibition of NLRP3-mediated pyroptosis.
Authors: Xu XJ; Air Force Medical Center, Fourth Military Medical University, 30 Fucheng Road, Haidian District, Beijing 100142, China., Shen K; Department of Emergency Medicine, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, Shaanxi Province, China., Ma YJ; Air Force Medical Center, Fourth Military Medical University, 30 Fucheng Road, Haidian District, Beijing 100142, China., Zhang XL; Air Force Medical Center, Fourth Military Medical University, 30 Fucheng Road, Haidian District, Beijing 100142, China., Wang Q; Air Force Medical Center, Fourth Military Medical University, 30 Fucheng Road, Haidian District, Beijing 100142, China., Liu P; Air Force Medical Center, Fourth Military Medical University, 30 Fucheng Road, Haidian District, Beijing 100142, China., He QF; Air Force Medical Center, Fourth Military Medical University, 30 Fucheng Road, Haidian District, Beijing 100142, China., Wang XQ; Department of Emergency Medicine, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, Shaanxi Province, China., Xu YN; Department of Emergency Medicine, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, Shaanxi Province, China., Fu HL; Department of Emergency Medicine, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, Shaanxi Province, China., Yang KX; Xijing Hospital, Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, Shaanxi Province, China., Li JJ; Department of Emergency Medicine, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, Shaanxi Province, China. Electronic address: lijunjie@fmmu.edu.cn., Luo ZX; Air Force Medical Center, Fourth Military Medical University, 30 Fucheng Road, Haidian District, Beijing 100142, China. Electronic address: luohanguoguo2020@163.com.
Source: International immunopharmacology [Int Immunopharmacol] 2026 Jul 01; Vol. 180, pp. 116666. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-1705
DOI:10.1016/j.intimp.2026.116666