Exogenous pyruvate restores mitochondrial bioenergetics by synergizing with the AMPK-mTOR-SIRT3 pathway to alleviate sepsis-associated acute kidney injury.
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| Title: | Exogenous pyruvate restores mitochondrial bioenergetics by synergizing with the AMPK-mTOR-SIRT3 pathway to alleviate sepsis-associated acute kidney injury. |
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| Authors: | Wang Y; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Wang W; Department of Emergency Medicine, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000, China., Sun J; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Zhou S; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Ni L; Department of Nephrology, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Dong M; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Wang X; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Graduate School of Bengbu Medical University, Bengbu, 233000, China., Yuan Y; Department of Intensive Care Unit, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, 314033, China., Wang J; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Graduate School of Bengbu Medical University, Bengbu, 233000, China., Ren P; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China; Graduate School of Bengbu Medical University, Bengbu, 233000, China., Fang W; Department of Animal Experiment Center, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China., Jin K; Department of Emergency Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, China. Electronic address: kuijin@ustc.edu.cn. |
| Source: | Chemico-biological interactions [Chem Biol Interact] 2026 Jul 01; Vol. 434, pp. 112089. Date of Electronic Publication: 2026 Apr 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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