Tumor-derived DNA drives cancer-associated anemia by promoting reticulocyte clearance.

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Title: Tumor-derived DNA drives cancer-associated anemia by promoting reticulocyte clearance.
Authors: Yuan T; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Liu X; Jinfeng Laboratory, Chongqing, China., Wu Y; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Li S; Jinfeng Laboratory, Chongqing, China., Chu H; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Li Q; Jinfeng Laboratory, Chongqing, China., Chen Z; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Liu H; Department of Immunology, Chongqing Medical University, Chongqing, China., Mao T; Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, China., Zha H; Department of Oncology, PLA Rocket Force Characteristic Medical Center, Beijing, China., Cheng X; TCRCure Biopharma, Durham, NC, USA., Jing J; Jinfeng Laboratory, Chongqing, China., Li C; Jinfeng Laboratory, Chongqing, China., Peng L; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Chen X; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Liao Q; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China., Yu R; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Lv H; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Zhang J; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Wang Z; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Jia Q; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Long H; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China. longhaixialhx@163.com.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China. longhaixialhx@163.com., Chen D; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China. degaochen@tmmu.edu.cn.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China. degaochen@tmmu.edu.cn., Zhu B; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China. bo.zhu@tmmu.edu.cn.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China. bo.zhu@tmmu.edu.cn.; Jinfeng Laboratory, Chongqing, China. bo.zhu@tmmu.edu.cn.; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China. bo.zhu@tmmu.edu.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Apr 24; Vol. 11 (1). Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2059-3635
DOI:10.1038/s41392-026-02674-9