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Tumor-derived DNA drives cancer-associated anemia by promoting reticulocyte clearance.

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Title: Tumor-derived DNA drives cancer-associated anemia by promoting reticulocyte clearance.
Authors: Yuan T; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Liu X; Jinfeng Laboratory, Chongqing, China., Wu Y; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Li S; Jinfeng Laboratory, Chongqing, China., Chu H; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Li Q; Jinfeng Laboratory, Chongqing, China., Chen Z; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Liu H; Department of Immunology, Chongqing Medical University, Chongqing, China., Mao T; Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, China., Zha H; Department of Oncology, PLA Rocket Force Characteristic Medical Center, Beijing, China., Cheng X; TCRCure Biopharma, Durham, NC, USA., Jing J; Jinfeng Laboratory, Chongqing, China., Li C; Jinfeng Laboratory, Chongqing, China., Peng L; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Chen X; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Liao Q; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China., Yu R; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Lv H; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Zhang J; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Wang Z; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Jia Q; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China., Long H; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China. longhaixialhx@163.com.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China. longhaixialhx@163.com., Chen D; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China. degaochen@tmmu.edu.cn.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China. degaochen@tmmu.edu.cn., Zhu B; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China. bo.zhu@tmmu.edu.cn.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China. bo.zhu@tmmu.edu.cn.; Jinfeng Laboratory, Chongqing, China. bo.zhu@tmmu.edu.cn.; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China. bo.zhu@tmmu.edu.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Apr 24; Vol. 11 (1). Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tumor-derived DNA drives cancer-associated anemia by promoting reticulocyte clearance.
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  Data: <searchLink fieldCode="AU" term="%22Yuan+T%22">Yuan T</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Jinfeng Laboratory, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Jinfeng Laboratory, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Chu+H%22">Chu H</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Jinfeng Laboratory, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Immunology, Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Mao+T%22">Mao T</searchLink>; Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, China.<br /><searchLink fieldCode="AU" term="%22Zha+H%22">Zha H</searchLink>; Department of Oncology, PLA Rocket Force Characteristic Medical Center, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cheng+X%22">Cheng X</searchLink>; TCRCure Biopharma, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Jing+J%22">Jing J</searchLink>; Jinfeng Laboratory, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Jinfeng Laboratory, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Peng+L%22">Peng L</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Liao+Q%22">Liao Q</searchLink>; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Yu+R%22">Yu R</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Lv+H%22">Lv H</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Jia+Q%22">Jia Q</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Long+H%22">Long H</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China. longhaixialhx@163.com.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China. longhaixialhx@163.com.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China. degaochen@tmmu.edu.cn.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China. degaochen@tmmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhu+B%22">Zhu B</searchLink>; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China. bo.zhu@tmmu.edu.cn.; Chongqing Key Laboratory of Immunotherapy, Chongqing, China. bo.zhu@tmmu.edu.cn.; Jinfeng Laboratory, Chongqing, China. bo.zhu@tmmu.edu.cn.; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China. bo.zhu@tmmu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41392-026-02674-9
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