TRPV4 mediates aminoglycoside trafficking and ototoxicity without compromising antimicrobial efficacy.

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Title: TRPV4 mediates aminoglycoside trafficking and ototoxicity without compromising antimicrobial efficacy.
Authors: Kong L; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan.; Department of Otolaryngology, Shanxi Children's Hospital, Taiyuan, China., Kurioka T; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan. kurioka.takaomi@kitasato-u.ac.jp.; School of Allied Health Science, Kitasato University, Sagamihara, Japan. kurioka.takaomi@kitasato-u.ac.jp., Mogi S; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan., Nitta Y; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan., Yamamoto K; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan., Yamashita T; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan.
Source: Cell death discovery [Cell Death Discov] 2026 Apr 25; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2058-7716
DOI:10.1038/s41420-026-03132-9