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TRPV4 mediates aminoglycoside trafficking and ototoxicity without compromising antimicrobial efficacy.

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Title: TRPV4 mediates aminoglycoside trafficking and ototoxicity without compromising antimicrobial efficacy.
Authors: Kong L; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan.; Department of Otolaryngology, Shanxi Children's Hospital, Taiyuan, China., Kurioka T; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan. kurioka.takaomi@kitasato-u.ac.jp.; School of Allied Health Science, Kitasato University, Sagamihara, Japan. kurioka.takaomi@kitasato-u.ac.jp., Mogi S; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan., Nitta Y; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan., Yamamoto K; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan., Yamashita T; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan.
Source: Cell death discovery [Cell Death Discov] 2026 Apr 25; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: TRPV4 mediates aminoglycoside trafficking and ototoxicity without compromising antimicrobial efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Kong+L%22">Kong L</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan.; Department of Otolaryngology, Shanxi Children's Hospital, Taiyuan, China.<br /><searchLink fieldCode="AU" term="%22Kurioka+T%22">Kurioka T</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan. kurioka.takaomi@kitasato-u.ac.jp.; School of Allied Health Science, Kitasato University, Sagamihara, Japan. kurioka.takaomi@kitasato-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Mogi+S%22">Mogi S</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Nitta+Y%22">Nitta Y</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+K%22">Yamamoto K</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Yamashita+T%22">Yamashita T</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Sagamihara, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Apr 25; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Apr 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41420-026-03132-9
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              Text: 2026 Apr 25
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