Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns.

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Title: Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns.
Authors: Deneuve S; Department of Otolaryngology-Head and Neck Surgery, CHU Rouen, Rouen, France.; QuantIF-LITIS Team EA4108, University of Rouen, Rouen, France., Fervers B; Centre Léon Bérard, Département Prévention Cancer Environment, INSERM U1296 Unit Radiation: Defense, Health Environment, Lyon, France., Bruno JS; International Agency for Research on Cancer WHO, Epigenomics and Mechanisms Branch, Lyon, France., Bach E; International Agency for Research on Cancer WHO, Epigenomics and Mechanisms Branch, Lyon, France.; Department of Maxillofacial and Facial Plastic Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France., Senkin S; International Agency for Research on Cancer WHO, Epigenomics and Mechanisms Branch, Lyon, France., Goldman-Lévy G; International Agency for Research on Cancer WHO, Evidence Synthesis and Classification Branch, Lyon, France., Carreira C; International Agency for Research on Cancer WHO, Evidence Synthesis and Classification Branch, Lyon, France., Laklouk I; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA., Hu R; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Bouaoun L; International Agency for Research on Cancer WHO, Environment and Lifestyle Epidemiology Branch, Lyon, France., Pérol O; Centre Léon Bérard, Département Prévention Cancer Environment, INSERM U1296 Unit Radiation: Defense, Health Environment, Lyon, France., Chavanel B; International Agency for Research on Cancer WHO, Epigenomics and Mechanisms Branch, Lyon, France., Lu L; Department of Chronic Disease Epidemiology, Yale School of Public Health, Medicine, New Haven, CT, USA.; Center for Biomedical Data Science, Yale University, New Haven, CT, USA.; Yale Cancer Center, Yale University, New Haven, CT, USA., Lozar T; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; University of Ljubljana, Ljubljana, Slovenia., Gheit T; International Agency for Research on Cancer WHO, Epigenomics and Mechanisms Branch, Lyon, France., Lambert PF; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Coste I; INSERM U1052-CNRS UMR5286, Cancer Research Center, University Claude Bernard Lyon 1, Centre Léon Bérard, Lyon, France., Renno T; INSERM U1052-CNRS UMR5286, Cancer Research Center, University Claude Bernard Lyon 1, Centre Léon Bérard, Lyon, France., Zavadil J; International Agency for Research on Cancer WHO, Epigenomics and Mechanisms Branch, Lyon, France. zavadilj@iarc.who.int., Virard F; INSERM U1052-CNRS UMR5286, Cancer Research Center, University Claude Bernard Lyon 1, Centre Léon Bérard, Lyon, France. francois.virard@univ-lyon1.fr.; Department of Oral Biology, Faculty of Dentistry, Lyon 1 University, Lyon, France. francois.virard@univ-lyon1.fr.; Odontology Center, Hospices Civils de Lyon, Lyon, France. francois.virard@univ-lyon1.fr.
Source: International journal of oral science [Int J Oral Sci] 2026 Apr 24; Vol. 18 (1). Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: India NLM ID: 101504351 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-3169 (Electronic) Linking ISSN: 16742818 NLM ISO Abbreviation: Int J Oral Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2049-3169
DOI:10.1038/s41368-026-00437-4