A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9+ myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity.

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Title: A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9+ myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity.
Authors: Wang Y; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Afshari K; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Haddadi NS; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lopes CS; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Eng CL; Spatial Genomics, Pasadena, CA, USA., Whiteman LM; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Martinez N; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kyawe PP; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Anufrieva KS; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA., Wei K; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA., Frieda K; Spatial Genomics, Pasadena, CA, USA., Rosenbach M; Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA., Vleugels RA; Department of Dermatology, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA., Gallucci S; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Harris JE; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Rashighi M; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA. mehdi.rashighi@umassmed.edu., Garber M; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. manuel.garber@umassmed.edu.
Source: Nature immunology [Nat Immunol] 2026 Jun; Vol. 27 (6), pp. 1184-1196. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1529-2916
DOI:10.1038/s41590-026-02502-w