A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9+ myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity.
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| Title: | A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9+ myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity. |
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| Authors: | Wang Y; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Afshari K; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Haddadi NS; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lopes CS; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Eng CL; Spatial Genomics, Pasadena, CA, USA., Whiteman LM; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Martinez N; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kyawe PP; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Anufrieva KS; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA., Wei K; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA., Frieda K; Spatial Genomics, Pasadena, CA, USA., Rosenbach M; Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA., Vleugels RA; Department of Dermatology, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA., Gallucci S; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Harris JE; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Rashighi M; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA. mehdi.rashighi@umassmed.edu., Garber M; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. manuel.garber@umassmed.edu. |
| Source: | Nature immunology [Nat Immunol] 2026 Jun; Vol. 27 (6), pp. 1184-1196. Date of Electronic Publication: 2026 Apr 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42032302 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9<superscript>+</superscript> myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Afshari+K%22">Afshari K</searchLink>; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Haddadi+NS%22">Haddadi NS</searchLink>; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lopes+CS%22">Lopes CS</searchLink>; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Eng+CL%22">Eng CL</searchLink>; Spatial Genomics, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Whiteman+LM%22">Whiteman LM</searchLink>; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+N%22">Martinez N</searchLink>; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kyawe+PP%22">Kyawe PP</searchLink>; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Anufrieva+KS%22">Anufrieva KS</searchLink>; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wei+K%22">Wei K</searchLink>; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Frieda+K%22">Frieda K</searchLink>; Spatial Genomics, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rosenbach+M%22">Rosenbach M</searchLink>; Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vleugels+RA%22">Vleugels RA</searchLink>; Department of Dermatology, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gallucci+S%22">Gallucci S</searchLink>; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Harris+JE%22">Harris JE</searchLink>; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rashighi+M%22">Rashighi M</searchLink>; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA. mehdi.rashighi@umassmed.edu.<br /><searchLink fieldCode="AU" term="%22Garber+M%22">Garber M</searchLink>; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. manuel.garber@umassmed.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2026 Jun; Vol. 27 (6), pp. 1184-1196. <i>Date of Electronic Publication: </i>2026 Apr 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+America+Inc%22">Nature America Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100941354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1529-2916 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215292908%22">15292908 </searchLink><i>NLM ISO Abbreviation: </i>Nat Immunol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42032302 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41590-026-02502-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1184 Titles: – TitleFull: A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9+ myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang Y – PersonEntity: Name: NameFull: Afshari K – PersonEntity: Name: NameFull: Haddadi NS – PersonEntity: Name: NameFull: Lopes CS – PersonEntity: Name: NameFull: Eng CL – PersonEntity: Name: NameFull: Whiteman LM – PersonEntity: Name: NameFull: Martinez N – PersonEntity: Name: NameFull: Kyawe PP – PersonEntity: Name: NameFull: Anufrieva KS – PersonEntity: Name: NameFull: Wei K – PersonEntity: Name: NameFull: Frieda K – PersonEntity: Name: NameFull: Rosenbach M – PersonEntity: Name: NameFull: Vleugels RA – PersonEntity: Name: NameFull: Gallucci S – PersonEntity: Name: NameFull: Harris JE – PersonEntity: Name: NameFull: Rashighi M – PersonEntity: Name: NameFull: Garber M IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1529-2916 Numbering: – Type: volume Value: 27 – Type: issue Value: 6 Titles: – TitleFull: Nature immunology Type: main |
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