Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability.

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Title: Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability.
Authors: D'Ambrosio M; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., White MEH; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.; The Francis Crick Institute, London, UK., Gavriil ES; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Bousset L; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Birch J; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Gruevska A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Pasquini E; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Colucci M; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Fong W; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Mosole S; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Valdata A; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Veroutis D; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Tyson K; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK., Ranvir V; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Prokosch S; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Pombo J; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Ardisson A; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Khadayate S; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Young G; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Montoya A; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Roumelioti G; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Houghton J; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Lu J; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Shliaha PV; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., De Vita E; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.; Centre for Molecular Cell Biology, Department of Biochemistry, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK., Vernia S; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; Institute of Biomedicine of Valencia, CSIC and Valencia Biomedical Research Foundation, Centro de Investigación Príncipe Felipe-associated unit to the IBV-CSICC, Valencia, Spain., Gorgoulis VG; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece.; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK., Gallage S; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Heikenwälder M; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Hall Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Alimonti A; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., McNeish IA; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK., Tate EW; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.; The Francis Crick Institute, London, UK., Gil J; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK. jesus.gil@imperial.ac.uk.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. jesus.gil@imperial.ac.uk.
Source: Nature cell biology [Nat Cell Biol] 2026 May; Vol. 28 (5), pp. 915-929. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4679
DOI:10.1038/s41556-026-01921-z