View in EDS

Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability.

Saved in:
Bibliographic Details
Title: Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability.
Authors: D'Ambrosio M; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., White MEH; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.; The Francis Crick Institute, London, UK., Gavriil ES; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Bousset L; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Birch J; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Gruevska A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Pasquini E; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Colucci M; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Fong W; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Mosole S; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Valdata A; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Veroutis D; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Tyson K; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK., Ranvir V; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Prokosch S; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Pombo J; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Ardisson A; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Khadayate S; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Young G; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Montoya A; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Roumelioti G; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Houghton J; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Lu J; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Shliaha PV; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., De Vita E; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.; Centre for Molecular Cell Biology, Department of Biochemistry, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK., Vernia S; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; Institute of Biomedicine of Valencia, CSIC and Valencia Biomedical Research Foundation, Centro de Investigación Príncipe Felipe-associated unit to the IBV-CSICC, Valencia, Spain., Gorgoulis VG; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece.; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK., Gallage S; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Heikenwälder M; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany., Hall Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Alimonti A; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., McNeish IA; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK., Tate EW; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.; The Francis Crick Institute, London, UK., Gil J; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK. jesus.gil@imperial.ac.uk.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. jesus.gil@imperial.ac.uk.
Source: Nature cell biology [Nat Cell Biol] 2026 May; Vol. 28 (5), pp. 915-929. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42032311
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22D'Ambrosio+M%22">D'Ambrosio M</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22White+MEH%22">White MEH</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Gavriil+ES%22">Gavriil ES</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bousset+L%22">Bousset L</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Birch+J%22">Birch J</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gruevska+A%22">Gruevska A</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pasquini+E%22">Pasquini E</searchLink>; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Colucci+M%22">Colucci M</searchLink>; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fong+W%22">Fong W</searchLink>; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mosole+S%22">Mosole S</searchLink>; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Valdata+A%22">Valdata A</searchLink>; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Veroutis+D%22">Veroutis D</searchLink>; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Tyson+K%22">Tyson K</searchLink>; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ranvir+V%22">Ranvir V</searchLink>; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Prokosch+S%22">Prokosch S</searchLink>; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pombo+J%22">Pombo J</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ardisson+A%22">Ardisson A</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Khadayate+S%22">Khadayate S</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Young+G%22">Young G</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Montoya+A%22">Montoya A</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Roumelioti+G%22">Roumelioti G</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Houghton+J%22">Houghton J</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Shliaha+PV%22">Shliaha PV</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22De+Vita+E%22">De Vita E</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.; Centre for Molecular Cell Biology, Department of Biochemistry, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Vernia+S%22">Vernia S</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; Institute of Biomedicine of Valencia, CSIC and Valencia Biomedical Research Foundation, Centro de Investigación Príncipe Felipe-associated unit to the IBV-CSICC, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Gorgoulis+VG%22">Gorgoulis VG</searchLink>; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece.; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Gallage+S%22">Gallage S</searchLink>; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Heikenwälder+M%22">Heikenwälder M</searchLink>; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.; German Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hall+Z%22">Hall Z</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Alimonti+A%22">Alimonti A</searchLink>; Institute of Oncology Research, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22McNeish+IA%22">McNeish IA</searchLink>; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tate+EW%22">Tate EW</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Gil+J%22">Gil J</searchLink>; MRC Laboratory of Medical Sciences, Du Cane Road, London, UK. jesus.gil@imperial.ac.uk.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. jesus.gil@imperial.ac.uk.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22100890575%22">Nature cell biology</searchLink> [Nat Cell Biol] 2026 May; Vol. 28 (5), pp. 915-929. <i>Date of Electronic Publication: </i>2026 Apr 24.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Macmillan+Magazines+Ltd%22">Macmillan Magazines Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100890575 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4679 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214657392%22">14657392 </searchLink><i>NLM ISO Abbreviation: </i>Nat Cell Biol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42032311
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41556-026-01921-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 915
    Titles:
      – TitleFull: Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: D'Ambrosio M
      – PersonEntity:
          Name:
            NameFull: White MEH
      – PersonEntity:
          Name:
            NameFull: Gavriil ES
      – PersonEntity:
          Name:
            NameFull: Bousset L
      – PersonEntity:
          Name:
            NameFull: Birch J
      – PersonEntity:
          Name:
            NameFull: Gruevska A
      – PersonEntity:
          Name:
            NameFull: Pasquini E
      – PersonEntity:
          Name:
            NameFull: Colucci M
      – PersonEntity:
          Name:
            NameFull: Fong W
      – PersonEntity:
          Name:
            NameFull: Mosole S
      – PersonEntity:
          Name:
            NameFull: Valdata A
      – PersonEntity:
          Name:
            NameFull: Veroutis D
      – PersonEntity:
          Name:
            NameFull: Tyson K
      – PersonEntity:
          Name:
            NameFull: Ranvir V
      – PersonEntity:
          Name:
            NameFull: Prokosch S
      – PersonEntity:
          Name:
            NameFull: Pombo J
      – PersonEntity:
          Name:
            NameFull: Ardisson A
      – PersonEntity:
          Name:
            NameFull: Khadayate S
      – PersonEntity:
          Name:
            NameFull: Young G
      – PersonEntity:
          Name:
            NameFull: Montoya A
      – PersonEntity:
          Name:
            NameFull: Roumelioti G
      – PersonEntity:
          Name:
            NameFull: Houghton J
      – PersonEntity:
          Name:
            NameFull: Lu J
      – PersonEntity:
          Name:
            NameFull: Shliaha PV
      – PersonEntity:
          Name:
            NameFull: De Vita E
      – PersonEntity:
          Name:
            NameFull: Vernia S
      – PersonEntity:
          Name:
            NameFull: Gorgoulis VG
      – PersonEntity:
          Name:
            NameFull: Gallage S
      – PersonEntity:
          Name:
            NameFull: Heikenwälder M
      – PersonEntity:
          Name:
            NameFull: Hall Z
      – PersonEntity:
          Name:
            NameFull: Alimonti A
      – PersonEntity:
          Name:
            NameFull: McNeish IA
      – PersonEntity:
          Name:
            NameFull: Tate EW
      – PersonEntity:
          Name:
            NameFull: Gil J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4679
          Numbering:
            – Type: volume
              Value: 28
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Nature cell biology
              Type: main
ResultId 1