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Inhibition of SARS-CoV-2 spike S1-ACE2 binding interaction and downregulation of ACE2 gene expression by Malaysian stingless bee honey and its bioactive compound, stilbamidine (SDC).

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Title: Inhibition of SARS-CoV-2 spike S1-ACE2 binding interaction and downregulation of ACE2 gene expression by Malaysian stingless bee honey and its bioactive compound, stilbamidine (SDC).
Authors: Ismail CMKH; Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.; Research Unit for Bioinformatics & Computational Biology (RUBIC), Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia., Ismail A; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia. dr_azlini@iium.edu.my., Mohd Abd Razak MR; Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Shah Alam, 40170, Selangor, Malaysia. ridzuan.ar@moh.gov.my., Abdul Hamid AA; Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.; Research Unit for Bioinformatics & Computational Biology (RUBIC), Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia., Mokhtar KI; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia., Lestari W; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia., Alahmad BEM; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.
Source: Molecular biology reports [Mol Biol Rep] 2026 Apr 25; Vol. 53 (1). Date of Electronic Publication: 2026 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-4978
DOI:10.1007/s11033-026-11698-x