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Inhibition of SARS-CoV-2 spike S1-ACE2 binding interaction and downregulation of ACE2 gene expression by Malaysian stingless bee honey and its bioactive compound, stilbamidine (SDC).

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Title: Inhibition of SARS-CoV-2 spike S1-ACE2 binding interaction and downregulation of ACE2 gene expression by Malaysian stingless bee honey and its bioactive compound, stilbamidine (SDC).
Authors: Ismail CMKH; Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.; Research Unit for Bioinformatics & Computational Biology (RUBIC), Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia., Ismail A; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia. dr_azlini@iium.edu.my., Mohd Abd Razak MR; Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Shah Alam, 40170, Selangor, Malaysia. ridzuan.ar@moh.gov.my., Abdul Hamid AA; Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.; Research Unit for Bioinformatics & Computational Biology (RUBIC), Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia., Mokhtar KI; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia., Lestari W; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia., Alahmad BEM; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.
Source: Molecular biology reports [Mol Biol Rep] 2026 Apr 25; Vol. 53 (1). Date of Electronic Publication: 2026 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of SARS-CoV-2 spike S1-ACE2 binding interaction and downregulation of ACE2 gene expression by Malaysian stingless bee honey and its bioactive compound, stilbamidine (SDC).
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  Data: <searchLink fieldCode="AU" term="%22Ismail+CMKH%22">Ismail CMKH</searchLink>; Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.; Research Unit for Bioinformatics & Computational Biology (RUBIC), Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.<br /><searchLink fieldCode="AU" term="%22Ismail+A%22">Ismail A</searchLink>; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia. dr_azlini@iium.edu.my.<br /><searchLink fieldCode="AU" term="%22Mohd+Abd+Razak+MR%22">Mohd Abd Razak MR</searchLink>; Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Shah Alam, 40170, Selangor, Malaysia. ridzuan.ar@moh.gov.my.<br /><searchLink fieldCode="AU" term="%22Abdul+Hamid+AA%22">Abdul Hamid AA</searchLink>; Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.; Research Unit for Bioinformatics & Computational Biology (RUBIC), Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.<br /><searchLink fieldCode="AU" term="%22Mokhtar+KI%22">Mokhtar KI</searchLink>; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.<br /><searchLink fieldCode="AU" term="%22Lestari+W%22">Lestari W</searchLink>; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.<br /><searchLink fieldCode="AU" term="%22Alahmad+BEM%22">Alahmad BEM</searchLink>; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia.
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  Data: <searchLink fieldCode="JN" term="%220403234%22">Molecular biology reports</searchLink> [Mol Biol Rep] 2026 Apr 25; Vol. 53 (1). <i>Date of Electronic Publication: </i>2026 Apr 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Reidel%22">Reidel </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0403234 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-4978 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203014851%22">03014851 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biol Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11033-026-11698-x
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      – Code: eng
        Text: English
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      – TitleFull: Inhibition of SARS-CoV-2 spike S1-ACE2 binding interaction and downregulation of ACE2 gene expression by Malaysian stingless bee honey and its bioactive compound, stilbamidine (SDC).
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              Text: 2026 Apr 25
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