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TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency.

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Title: TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency.
Authors: Kafkia E; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pladevall-Morera D; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Argemi-Muntadas L; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wang G; Department of Internal Medicine (Nephrology) & Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands; Novo Nordisk Foundation Centre for Stem Cell Medicine-reNEW, Leiden University Medical Centre, Leiden, the Netherlands., Noberini R; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20139 Milan, Italy., Casòliba-Melich A; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bagés-Arnal S; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Anagho-Mattanovich M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Silvério-Alves R; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gassler J; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bonaldi T; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20139 Milan, Italy; Department of Oncology and Hematology-Oncology, University of Milano, 20122 Milano, Italy., Rabelink TJ; Department of Internal Medicine (Nephrology) & Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands; Novo Nordisk Foundation Centre for Stem Cell Medicine-reNEW, Leiden University Medical Centre, Leiden, the Netherlands., Moritz T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Żylicz JJ; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: jan.zylicz@sund.ku.dk.
Source: Cell stem cell [Cell Stem Cell] 2026 May 07; Vol. 33 (5), pp. 820-836.e9. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1875-9777
DOI:10.1016/j.stem.2026.04.004