TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency.

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Title: TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency.
Authors: Kafkia E; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pladevall-Morera D; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Argemi-Muntadas L; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wang G; Department of Internal Medicine (Nephrology) & Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands; Novo Nordisk Foundation Centre for Stem Cell Medicine-reNEW, Leiden University Medical Centre, Leiden, the Netherlands., Noberini R; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20139 Milan, Italy., Casòliba-Melich A; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bagés-Arnal S; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Anagho-Mattanovich M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Silvério-Alves R; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gassler J; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bonaldi T; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20139 Milan, Italy; Department of Oncology and Hematology-Oncology, University of Milano, 20122 Milano, Italy., Rabelink TJ; Department of Internal Medicine (Nephrology) & Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands; Novo Nordisk Foundation Centre for Stem Cell Medicine-reNEW, Leiden University Medical Centre, Leiden, the Netherlands., Moritz T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Żylicz JJ; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: jan.zylicz@sund.ku.dk.
Source: Cell stem cell [Cell Stem Cell] 2026 May 07; Vol. 33 (5), pp. 820-836.e9. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency.
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  Data: <searchLink fieldCode="AU" term="%22Kafkia+E%22">Kafkia E</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Pladevall-Morera+D%22">Pladevall-Morera D</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Argemi-Muntadas+L%22">Argemi-Muntadas L</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Department of Internal Medicine (Nephrology) & Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands; Novo Nordisk Foundation Centre for Stem Cell Medicine-reNEW, Leiden University Medical Centre, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Noberini+R%22">Noberini R</searchLink>; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20139 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Casòliba-Melich+A%22">Casòliba-Melich A</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bagés-Arnal+S%22">Bagés-Arnal S</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Anagho-Mattanovich+M%22">Anagho-Mattanovich M</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Silvério-Alves+R%22">Silvério-Alves R</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Gassler+J%22">Gassler J</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bonaldi+T%22">Bonaldi T</searchLink>; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20139 Milan, Italy; Department of Oncology and Hematology-Oncology, University of Milano, 20122 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Rabelink+TJ%22">Rabelink TJ</searchLink>; Department of Internal Medicine (Nephrology) & Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands; Novo Nordisk Foundation Centre for Stem Cell Medicine-reNEW, Leiden University Medical Centre, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Moritz+T%22">Moritz T</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Żylicz+JJ%22">Żylicz JJ</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine-reNEW, Department of Biomolecular Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: jan.zylicz@sund.ku.dk.
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  Data: <searchLink fieldCode="JN" term="%22101311472%22">Cell stem cell</searchLink> [Cell Stem Cell] 2026 May 07; Vol. 33 (5), pp. 820-836.e9. <i>Date of Electronic Publication: </i>2026 Apr 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101311472 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1875-9777 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218759777%22">18759777 </searchLink><i>NLM ISO Abbreviation: </i>Cell Stem Cell <i>Subsets: </i>MEDLINE
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