Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer's pathology and cognitive resilience.

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Title: Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer's pathology and cognitive resilience.
Authors: Tosoni G; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Ayyildiz D; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Snoeck S; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Moreno-Jiménez EP; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Penning A; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Santiago-Mujika E; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA., Ruiz Ormaechea O; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Lee H; Basic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Poovathingal S; VIB Center for Brain & Disease Research, Leuven, Belgium; VIB-KU Leuven Center for Brain & Disease Research Technologies, Single Cell Microfluidics & Analytics Unit, Leuven, Belgium., Davie K; VIB Center for Brain & Disease Research, Leuven, Belgium; VIB-KU Leuven Center for Brain & Disease Research Technologies, Single Cell Bioinformatics Unit, Leuven, Belgium., Bryois J; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Macnair W; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Anink J; Amsterdam UMC location University of Amsterdam, Department of (Neuro)Pathology, Amsterdam, the Netherlands., De Vries LE; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Farmand S; Basic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Nutma E; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Swaab DF; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Aronica E; Amsterdam UMC location University of Amsterdam, Department of (Neuro)Pathology, Amsterdam, the Netherlands., Middeldorp J; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Thuret S; Basic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Roybon L; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA., Basak O; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Fitzsimons CP; Brain Plasticity Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands., Lucassen PJ; Brain Plasticity Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands., Salta E; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands. Electronic address: e.salta@nin.knaw.nl.
Source: Cell stem cell [Cell Stem Cell] 2026 May 07; Vol. 33 (5), pp. 763-783.e9. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1875-9777
DOI:10.1016/j.stem.2026.04.002