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Spatial predictors of response to chemo-immunotherapy in microsatellite stable metastatic colorectal cancer.

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Title: Spatial predictors of response to chemo-immunotherapy in microsatellite stable metastatic colorectal cancer.
Authors: Choo J; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Zhao JJ; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lau MC; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore., Raimondi A; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Yim WW; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Ranganathan S; Department of Medicine, University of Cambridge, Cambridge, UK., Zhu K; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Tan CTY; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore., Chin HX; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore., Teo CB; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Fong KY; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tay RYK; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lee JJ; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore.; Digital Analytics Laboratory, ImmunoQs Pte. Ltd., Singapore, Singapore., Loo LH; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore.; Digital Analytics Laboratory, ImmunoQs Pte. Ltd., Singapore, Singapore., Manca P; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Morano F; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Prisciandaro M; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Randon G; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Damonte C; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Micarelli E; Nouscom, Rome, Italy., Leoni G; Nouscom, Rome, Italy., Scarselli E; Nouscom, Rome, Italy., Lonardi S; Department of Oncology, Veneto Institute of Oncology IRCCS, Padova, Italy., Cremolini C; Unit of Medical Oncology 2, University Hospital of Pisa, Pisa, Italy., Marmorino F; Unit of Medical Oncology 2, University Hospital of Pisa, Pisa, Italy., Lim JCT; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.; Digital Analytics Laboratory, ImmunoQs Pte. Ltd., Singapore, Singapore., Neo ZW; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Wee F; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Chong LY; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Joseph CR; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Balachander A; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore., Lim DG; Department of Pathology, National University Health System, Singapore, Singapore., Hwang YY; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore., Renia L; Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore, Singapore.; ASTAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Biswas SK; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore.; Ignaz Semmelweis Institute, Interuniversity Institute of Infection Research and Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Tan D; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yeong JPS; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Sundar R; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore. raghav.sundar@yale.edu.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. raghav.sundar@yale.edu.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore. raghav.sundar@yale.edu.; Department of Medicine, Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA. raghav.sundar@yale.edu., Pietrantonio F; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. filippo.pietrantonio@istitutotumori.mi.it.
Source: Nature communications [Nat Commun] 2026 Apr 25; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Choo+J%22">Choo J</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhao+JJ%22">Zhao JJ</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lau+MC%22">Lau MC</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Raimondi+A%22">Raimondi A</searchLink>; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Yim+WW%22">Yim WW</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ranganathan+S%22">Ranganathan S</searchLink>; Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Zhu+K%22">Zhu K</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+CTY%22">Tan CTY</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chin+HX%22">Chin HX</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Teo+CB%22">Teo CB</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Fong+KY%22">Fong KY</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+RYK%22">Tay RYK</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+JJ%22">Lee JJ</searchLink>; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A⁎STAR), Singapore, Singapore.; Digital Analytics Laboratory, ImmunoQs Pte. 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