Eculizumab for Pediatric Hematopoietic Cell Transplant-Associated Thrombotic Microangiopathy: Real-World Response Rates, Predictors of Poor Response, and an Optimal Time Point for Treatment Response Assessment.
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| Title: | Eculizumab for Pediatric Hematopoietic Cell Transplant-Associated Thrombotic Microangiopathy: Real-World Response Rates, Predictors of Poor Response, and an Optimal Time Point for Treatment Response Assessment. |
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| Authors: | Schoettler ML; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia. Electronic address: Michelle.Schoettler@emory.edu., Cheng G; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplant, University of California San Francisco, Benioff Children's Hospitals, San Francisco, California., Higham CS; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplant, University of California San Francisco, Benioff Children's Hospitals, San Francisco, California., Dvorak CC; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplant, University of California San Francisco, Benioff Children's Hospitals, San Francisco, California., Rush C; Department of Pediatric Hematology, Oncology, Blood and Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio and Department of Pediatrics, The Ohio State University, Columbus, Ohio., Rangarajan HG; Department of Pediatric Hematology, Oncology, Blood and Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio and Department of Pediatrics, The Ohio State University, Columbus, Ohio., Al-Nazer M; Department of Pediatric Hematology, Oncology, Blood and Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio and Department of Pediatrics, The Ohio State University, Columbus, Ohio., Polishchuk V; Lurie Children's Hospital of Chicago, Chicago, Illinois., Chaudhury S; Lurie Children's Hospital of Chicago, Chicago, Illinois., Lehmann L; Boston Children's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts., Duncan C; Boston Children's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts., Nishitani M; Boston Children's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts., Manougian H; Cleveland Clinic, Cleveland, Ohio., Rotz S; Cleveland Clinic, Cleveland, Ohio., Ofori J; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia., Frost E; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia., Orbodo J; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia., Spencer K; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia., Kenney E; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia., Chonat S; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia., Chewning J; Children's of Alabama, Birmingham, Alabama., Moore C; Children's of Alabama, Birmingham, Alabama., Westbrook A; Pediatric Biostatistics Core, Department of Pediatrics, Emory University, Atlanta, Georgia., Williams KM; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia. |
| Source: | Transplantation and cellular therapy [Transplant Cell Ther] 2026 Jul; Vol. 32 (7), pp. 887.e1-887.e16. Date of Electronic Publication: 2026 Apr 24. |
| Publication Type: | Journal Article; Multicenter Study; Observational Study |
| Journal Info: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101774629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-6367 (Electronic) Linking ISSN: 26666367 NLM ISO Abbreviation: Transplant Cell Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42035874 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Eculizumab for Pediatric Hematopoietic Cell Transplant-Associated Thrombotic Microangiopathy: Real-World Response Rates, Predictors of Poor Response, and an Optimal Time Point for Treatment Response Assessment. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Schoettler+ML%22">Schoettler ML</searchLink>; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia. Electronic address: Michelle.Schoettler@emory.edu.<br /><searchLink fieldCode="AU" term="%22Cheng+G%22">Cheng G</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplant, University of California San Francisco, Benioff Children's Hospitals, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Higham+CS%22">Higham CS</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplant, University of California San Francisco, Benioff Children's Hospitals, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Dvorak+CC%22">Dvorak CC</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplant, University of California San Francisco, Benioff Children's Hospitals, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Rush+C%22">Rush C</searchLink>; Department of Pediatric Hematology, Oncology, Blood and Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio and Department of Pediatrics, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Rangarajan+HG%22">Rangarajan HG</searchLink>; Department of Pediatric Hematology, Oncology, Blood and Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio and Department of Pediatrics, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Al-Nazer+M%22">Al-Nazer M</searchLink>; Department of Pediatric Hematology, Oncology, Blood and Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio and Department of Pediatrics, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Polishchuk+V%22">Polishchuk V</searchLink>; Lurie Children's Hospital of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Chaudhury+S%22">Chaudhury S</searchLink>; Lurie Children's Hospital of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Lehmann+L%22">Lehmann L</searchLink>; Boston Children's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Duncan+C%22">Duncan C</searchLink>; Boston Children's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Nishitani+M%22">Nishitani M</searchLink>; Boston Children's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Manougian+H%22">Manougian H</searchLink>; Cleveland Clinic, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Rotz+S%22">Rotz S</searchLink>; Cleveland Clinic, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Ofori+J%22">Ofori J</searchLink>; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Frost+E%22">Frost E</searchLink>; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Orbodo+J%22">Orbodo J</searchLink>; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Spencer+K%22">Spencer K</searchLink>; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Kenney+E%22">Kenney E</searchLink>; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Chonat+S%22">Chonat S</searchLink>; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Chewning+J%22">Chewning J</searchLink>; Children's of Alabama, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Moore+C%22">Moore C</searchLink>; Children's of Alabama, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Westbrook+A%22">Westbrook A</searchLink>; Pediatric Biostatistics Core, Department of Pediatrics, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Williams+KM%22">Williams KM</searchLink>; Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, Georgia. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101774629%22">Transplantation and cellular therapy</searchLink> [Transplant Cell Ther] 2026 Jul; Vol. 32 (7), pp. 887.e1-887.e16. <i>Date of Electronic Publication: </i>2026 Apr 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Multicenter Study; Observational Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101774629 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-6367 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226666367%22">26666367 </searchLink><i>NLM ISO Abbreviation: </i>Transplant Cell Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42035874 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jtct.2026.04.026 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 887.e1-887.e16 Titles: – TitleFull: Eculizumab for Pediatric Hematopoietic Cell Transplant-Associated Thrombotic Microangiopathy: Real-World Response Rates, Predictors of Poor Response, and an Optimal Time Point for Treatment Response Assessment. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Schoettler ML – PersonEntity: Name: NameFull: Cheng G – PersonEntity: Name: NameFull: Higham CS – PersonEntity: Name: NameFull: Dvorak CC – PersonEntity: Name: NameFull: Rush C – PersonEntity: Name: NameFull: Rangarajan HG – PersonEntity: Name: NameFull: Al-Nazer M – PersonEntity: Name: NameFull: Polishchuk V – PersonEntity: Name: NameFull: Chaudhury S – PersonEntity: Name: NameFull: Lehmann L – PersonEntity: Name: NameFull: Duncan C – PersonEntity: Name: NameFull: Nishitani M – PersonEntity: Name: NameFull: Manougian H – PersonEntity: Name: NameFull: Rotz S – PersonEntity: Name: NameFull: Ofori J – PersonEntity: Name: NameFull: Frost E – PersonEntity: Name: NameFull: Orbodo J – PersonEntity: Name: NameFull: Spencer K – PersonEntity: Name: NameFull: Kenney E – PersonEntity: Name: NameFull: Chonat S – PersonEntity: Name: NameFull: Chewning J – PersonEntity: Name: NameFull: Moore C – PersonEntity: Name: NameFull: Westbrook A – PersonEntity: Name: NameFull: Williams KM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2666-6367 Numbering: – Type: volume Value: 32 – Type: issue Value: 7 Titles: – TitleFull: Transplantation and cellular therapy Type: main |
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