Inflammatory Biomarkers as Mediators of the Effect Between High-Dose Corticosteroid Therapy and Mortality in COVID-19-Related ARDS: A Causal Mediation Analysis.

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Title: Inflammatory Biomarkers as Mediators of the Effect Between High-Dose Corticosteroid Therapy and Mortality in COVID-19-Related ARDS: A Causal Mediation Analysis.
Authors: Daenen K; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., Boyd A; Stichting HIV Monitoring, Amsterdam, the Netherlands.; Infectious Diseases, Amsterdam University Medical Centers, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Dalm VASH; Department of Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Internal Medicine, Division of Allergy & Clinical Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., Huijben JA; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands., Stoof SCM; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands., Bos LDJ; Department of Intensive Care, Amsterdam University Medical Centers, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands., Gommers D; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands., Schinkel J; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., van Gorp ECM; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Endeman H; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Intensive Care, OLVG, Amsterdam, the Netherlands.
Source: Immunity, inflammation and disease [Immun Inflamm Dis] 2026 Apr; Vol. 14 (4), pp. e70427.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley and Sons Ltd Country of Publication: England NLM ID: 101635460 Publication Model: Print Cited Medium: Internet ISSN: 2050-4527 (Electronic) Linking ISSN: 20504527 NLM ISO Abbreviation: Immun Inflamm Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2050-4527
DOI:10.1002/iid3.70427