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Inflammatory Biomarkers as Mediators of the Effect Between High-Dose Corticosteroid Therapy and Mortality in COVID-19-Related ARDS: A Causal Mediation Analysis.

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Title: Inflammatory Biomarkers as Mediators of the Effect Between High-Dose Corticosteroid Therapy and Mortality in COVID-19-Related ARDS: A Causal Mediation Analysis.
Authors: Daenen K; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., Boyd A; Stichting HIV Monitoring, Amsterdam, the Netherlands.; Infectious Diseases, Amsterdam University Medical Centers, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Dalm VASH; Department of Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Internal Medicine, Division of Allergy & Clinical Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., Huijben JA; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands., Stoof SCM; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands., Bos LDJ; Department of Intensive Care, Amsterdam University Medical Centers, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands., Gommers D; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands., Schinkel J; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., van Gorp ECM; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Endeman H; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Intensive Care, OLVG, Amsterdam, the Netherlands.
Source: Immunity, inflammation and disease [Immun Inflamm Dis] 2026 Apr; Vol. 14 (4), pp. e70427.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley and Sons Ltd Country of Publication: England NLM ID: 101635460 Publication Model: Print Cited Medium: Internet ISSN: 2050-4527 (Electronic) Linking ISSN: 20504527 NLM ISO Abbreviation: Immun Inflamm Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Daenen+K%22">Daenen K</searchLink>; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boyd+A%22">Boyd A</searchLink>; Stichting HIV Monitoring, Amsterdam, the Netherlands.; Infectious Diseases, Amsterdam University Medical Centers, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dalm+VASH%22">Dalm VASH</searchLink>; Department of Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Internal Medicine, Division of Allergy & Clinical Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Huijben+JA%22">Huijben JA</searchLink>; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Stoof+SCM%22">Stoof SCM</searchLink>; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bos+LDJ%22">Bos LDJ</searchLink>; Department of Intensive Care, Amsterdam University Medical Centers, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gommers+D%22">Gommers D</searchLink>; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schinkel+J%22">Schinkel J</searchLink>; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Gorp+ECM%22">van Gorp ECM</searchLink>; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Endeman+H%22">Endeman H</searchLink>; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Intensive Care, OLVG, Amsterdam, the Netherlands.
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              Text: 2026 Apr
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