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Pharmacological inhibition of sclerostin protects bone from B-cell acute lymphoblastic leukemia-mediated destruction.

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Title: Pharmacological inhibition of sclerostin protects bone from B-cell acute lymphoblastic leukemia-mediated destruction.
Authors: Kuek V; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.; School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia.; School of Biomedical Sciences University of Western Australia Perth Western Australia Australia., Oommen J; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia., Ferrari E; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia., Yuan J; School of Biomedical Sciences University of Western Australia Perth Western Australia Australia., Economides AN; Regeneron Pharmaceuticals Inc. Tarrytown New York United States., Lock RB; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Malinge S; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.; School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia.; School of Biomedical Sciences University of Western Australia Perth Western Australia Australia., Kotecha RS; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.; School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia.; School of Medicine University of Western Australia Perth Western Australia Australia.; Department of Clinical Haematology Oncology, Blood and Marrow Transplantation, Perth Children's Hospital Perth Western Australia Australia., Cheung LC; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.; School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia.; Curtin Medical Research Institute Curtin University Perth Western Australia Australia.
Source: HemaSphere [Hemasphere] 2026 Mar 31; Vol. 10 (4), pp. e70355. Date of Electronic Publication: 2026 Mar 31 (Print Publication: 2026).
Publication Type: Letter
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacological inhibition of sclerostin protects bone from B-cell acute lymphoblastic leukemia-mediated destruction.
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  Data: <searchLink fieldCode="AU" term="%22Kuek+V%22">Kuek V</searchLink>; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.; School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia.; School of Biomedical Sciences University of Western Australia Perth Western Australia Australia.<br /><searchLink fieldCode="AU" term="%22Oommen+J%22">Oommen J</searchLink>; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.<br /><searchLink fieldCode="AU" term="%22Ferrari+E%22">Ferrari E</searchLink>; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.<br /><searchLink fieldCode="AU" term="%22Yuan+J%22">Yuan J</searchLink>; School of Biomedical Sciences University of Western Australia Perth Western Australia Australia.<br /><searchLink fieldCode="AU" term="%22Economides+AN%22">Economides AN</searchLink>; Regeneron Pharmaceuticals Inc. Tarrytown New York United States.<br /><searchLink fieldCode="AU" term="%22Lock+RB%22">Lock RB</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Malinge+S%22">Malinge S</searchLink>; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.; School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia.; School of Biomedical Sciences University of Western Australia Perth Western Australia Australia.<br /><searchLink fieldCode="AU" term="%22Kotecha+RS%22">Kotecha RS</searchLink>; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.; School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia.; School of Medicine University of Western Australia Perth Western Australia Australia.; Department of Clinical Haematology Oncology, Blood and Marrow Transplantation, Perth Children's Hospital Perth Western Australia Australia.<br /><searchLink fieldCode="AU" term="%22Cheung+LC%22">Cheung LC</searchLink>; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia.; School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia.; Curtin Medical Research Institute Curtin University Perth Western Australia Australia.
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  Data: <searchLink fieldCode="JN" term="%22101740619%22">HemaSphere</searchLink> [Hemasphere] 2026 Mar 31; Vol. 10 (4), pp. e70355. <i>Date of Electronic Publication: </i>2026 Mar 31 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101740619 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2572-9241 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225729241%22">25729241 </searchLink><i>NLM ISO Abbreviation: </i>Hemasphere <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Mar 31
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