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Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway.

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Title: Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway.
Authors: Baraka SM; Chemistry of Natural Compounds Department, National Research Centre, Giza, 12622, Egypt. sarascience11@yahoo.com., El-Gendy ZA; Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt., El-Abd EAW; Pharmacognosy Department, National Research Centre (NRC), El Behouth St., P.O. 12622, Cairo, Egypt., El-Sayed AF; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Dokki, Giza, 12622, Egypt.; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt., Omara EA; Pathology Department, National Research Centre, Dokki, Cairo, Egypt., Elbatanony MM; Pharmacognosy Department, National Research Centre (NRC), El Behouth St., P.O. 12622, Cairo, Egypt.
Source: Inflammopharmacology [Inflammopharmacology] 2026 Jun; Vol. 34 (6), pp. 4197-4218. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway.
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  Data: <searchLink fieldCode="AU" term="%22Baraka+SM%22">Baraka SM</searchLink>; Chemistry of Natural Compounds Department, National Research Centre, Giza, 12622, Egypt. sarascience11@yahoo.com.<br /><searchLink fieldCode="AU" term="%22El-Gendy+ZA%22">El-Gendy ZA</searchLink>; Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Abd+EAW%22">El-Abd EAW</searchLink>; Pharmacognosy Department, National Research Centre (NRC), El Behouth St., P.O. 12622, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sayed+AF%22">El-Sayed AF</searchLink>; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Dokki, Giza, 12622, Egypt.; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Omara+EA%22">Omara EA</searchLink>; Pathology Department, National Research Centre, Dokki, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Elbatanony+MM%22">Elbatanony MM</searchLink>; Pharmacognosy Department, National Research Centre (NRC), El Behouth St., P.O. 12622, Cairo, Egypt.
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  Data: <searchLink fieldCode="JN" term="%229112626%22">Inflammopharmacology</searchLink> [Inflammopharmacology] 2026 Jun; Vol. 34 (6), pp. 4197-4218. <i>Date of Electronic Publication: </i>2026 Apr 27.
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        Value: 10.1007/s10787-026-02245-y
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      – TitleFull: Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway.
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              Text: 2026 Jun
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